微RNA-34a在新疆维吾尔族和汉族慢性淋巴细胞白血病患者的表达及其预后意义  

The expression and prognostic significance of microRNA-34a in Uygur and Han patients with chronic lymphocytic leukemia in Xinjiang Uygur Autonomous Region in China

作　　者：刘虹[1] 王晓敏[1] 毛敏[1] 富玲[1] 黄琴[1] 王一琳 王一淳[1] 王增胜[1] 李燕[1] Liu Hong;Wang Xiaomin;Mao Min;Fu Ling;Huang Qin;Wang Yilin;Wang Yichun;Wang Zengsheng;Li Yan(Department of Hematology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院血液病科,乌鲁木齐830001

出　　处：《中华内科杂志》2018年第12期922-925,共4页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金(81640033);新疆维吾尔自治区自然科学基金(2017D01C116)

摘　　要：本研究旨在探讨微RNA-34a(miR-34a)在新疆维吾尔族及汉族慢性淋巴细胞白血病(CLL)患者中的表达情况并分析其临床意义。研究结果表明,miR-34a的表达在维吾尔族及汉族CLL患者中均显著高于同民族健康对照,而这两个民族CLL患者miR-34a表达无明显差异;和已知预后因素进行对比研究并绘制ROC曲线分析,结果显示miR-34a对于CLL的预后具有良好的预测价值(miR-34a相对表达水平分界值为3.567 6),再按照miR-34a表达水平分组进行生存分析,提示miR-34a低表达组预后较差。To investigate the expression of microRNA-34a (miR-34a) in patients with chronic lymphocytic leukemia (CLL) in Xinjiang Uygur and Han nationalities and its prognostic significance. Our data showed that miR-34a expression in Uygur and Han CLL patients was significantly higher than that in their respective healthy controls, while miR-34a levels were similar between Uygur and Han patients. By comparing with known prognostic factors, receiver operating characteristic (ROC) curves showed that miR-34a was a good predictive factor for the prognosis of CLL (demarcation value was 3.567 6). Survival analysis was further performed according to miR-34a expression level, that low expression of miR-34a translated into poor prognosis.

关 键 词：白血病 淋巴细胞 慢性 B细胞 维吾尔族 微RNA-34a 预后 

分 类 号：R733.72[医药卫生—肿瘤]