低氧诱导因子-1α参与慢性粒细胞白血病发病机制的研究进展  

The research progress of hypoxia inducible factor-1α in the pathogenesis of chronic myeloid leukemia

作　　者：侯艳 李文倩[2] 冯建明[2] 解友邦[2] Hou Yan;Li Wenqian;Feng Jianming;Xie Youbang(Graduate School,Qinghai University ,Xining810016,China;Department of Blood Rheumatology ,Qing-hai Provincial People's Hospital,Xining 810007,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海省人民医院血液风湿科,西宁810007

出　　处：《国际免疫学杂志》2018年第5期578-581,共4页International Journal of Immunology

基　　金：2016年省卫生计生委科研课题和适宜技术推广项目(2016-wjdx-17);2014年度青海省人才“小高地”项目(青人才字[2014]12号);2011年度国家临床重点专科建设项目(卫办医政函[2011]873号)。

摘　　要：慢性粒细胞白血病(chronic myeloid leukemia,CML)作为一种造血系统的恶性肿瘤,在我国发病率为0.36/10万,并且在各类白血病中占第3位。低氧诱导因子1α(hypoxia inducible factor,HIF-1α)作为维持氧平衡的转录因子,在肺癌、胃癌、乳腺癌等实体肿瘤的发病中起着一定的作用,近期研究显示它在CML的发病中也起着关键的作用,因此有必要就HIF-1α通过对CML造血微环境、血管生成、耐药等方面的影响做一综述。Chronic myelogenous leukemia(CML)is a hematopoietic malignancy with a prevalence of 0.36 per 100000in China and is the third most common leukemia among all types.As a transcription factor for maintaining oxygen balance,hypoxia inducible factor (HIF)-1α plays a role in the pathogenesis of solid tumors such as lung cancer,gastric cancer,and breast cancer.The recent evidence suggests that HIF-1α lpha may be an important factor in the pathogenisis of CML.This article reviews the effects of HIF-1α on the hematopoietic microenvironment,angiogenesis,and drug resistance of CML.

关 键 词：慢性粒细胞白血病 低氧诱导因子 发病机制 

分 类 号：R733.72[医药卫生—肿瘤]