A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex  

作　　者：Lingchi Xu Yalan Wan Longyu Ma Jie Zheng Bingxuan Han Feng-Yu Liu Ming Yi You Wan 

机构地区：[1]Neuroscience Research Institute, Peking University [2]Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-Sen University [3]Department of Neurobiology, School of Basic Medical Sciences, Peking University [4]Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University [5]Co-innovation Center of Neuroregeneration, Nantong University

出　　处：《Neuroscience Bulletin》2018年第6期1047-1057,共11页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (91732107, 31200835, 81571067, and 81521063);the National Basic Research Development Program (973 Program) of China (2014CB548200 and 2015CB554503)

摘　　要：Cognition and pain share common neural substrates and interact reciprocally: chronic pain compromises cognitive performance, whereas cognitive processes modulate pain perception. In the present study, we established a non-drug-dependent rat model of context-based analgesia,where two different contexts(dark and bright) were matched with a high(52°C) or low(48°C) temperature in the hot-plate test during training. Before and after training,we set the temperature to the high level in both contexts.Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature, indicating successful establishment of a context-based analgesic effect in rats. This effect was blocked by intraperitoneal injection of naloxone(an opioid receptor antagonist) before the probe. The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex. In brief, we established a context-based, non-drug dependent, placebo-like analgesia model in the rat. This model provides a new and useful tool for investigating the cognitive modulation of pain.Cognition and pain share common neural substrates and interact reciprocally: chronic pain compromises cognitive performance, whereas cognitive processes modulate pain perception. In the present study, we established a non-drug-dependent rat model of context-based analgesia,where two different contexts(dark and bright) were matched with a high(52°C) or low(48°C) temperature in the hot-plate test during training. Before and after training,we set the temperature to the high level in both contexts.Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature, indicating successful establishment of a context-based analgesic effect in rats. This effect was blocked by intraperitoneal injection of naloxone(an opioid receptor antagonist) before the probe. The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex. In brief, we established a context-based, non-drug dependent, placebo-like analgesia model in the rat. This model provides a new and useful tool for investigating the cognitive modulation of pain.

关 键 词：Context-based analgesia Placebo analgesia Pain Hot-plate test Cognition modulation Opioid system Prefrontal cortex 

分 类 号：R[医药卫生]