三联疗法联合益生菌治疗儿童幽门螺杆菌感染的疗效  

Clinical efficacy of triple therapy combined with probiotics in the treatment of children with Helicobacter pylori infection

作　　者：董娜[1] 徐伟[1] 朱丹荣[1] 盛伟松[1] DONG Na;XU Wei;ZHU Danrong(Children's Medical Center,Second Affiliated Hospital,Nanjing Medical University,Nanjing 210003,CHINA)

机构地区：[1]南京医科大学第二附属医院儿童医学中心,江苏210003

出　　处：《江苏医药》2018年第11期1287-1289,共3页Jiangsu Medical Journal

摘　　要：目的探讨三联疗法联合不同益生菌治疗儿童幽门螺杆菌(Hp)感染的临床疗效。方法将240例感染Hp的患儿随机均分为三组:A组采用奥美拉唑、阿莫西林、克拉霉素三联疗法;在三联疗法的基础上,B组加用双歧杆菌乳杆菌嗜热链球菌三联活菌片,C组加用布拉氏酵母菌散剂。比较三组Hp根除率及不良反应发生率。结果 C组患儿Hp根除率高于A组和B组(88.75%vs.72.50%和75.00%)(P<0.05);B组和C组不良反应发生率低于A组(12.50%和10.00%vs.26.25%)(P<0.05)。结论三联疗法联合益生菌治疗Hp感染能显著降低治疗过程中不良反应发生率,而应用布拉氏酵母菌散剂更可以提高三联疗法的Hp根除率。Objective To investigate the clinical efficacy of triple therapy combined with different kinds of probiotics in the treatment of children with Helicobacter pylori (Hp)infection. Methods A total of 240 children with Hp infection was equally randomized into three groups.Group A was only treated with triple therapy including omeprazole,amoxicillin and clarithromycin.On the basis of triple therapy as in group A,groups B was additionally given Bifidobacterium,Lactobacillus and Streptococcus tablets and group C was additionally given Saccharomyces boulardii sachets.The eradication rate of Hp and incidence of adverse response were compared among three groups.Results The eradication rate of Hp in group C was significantly higher than that in groups of A and B (88.75% vs.72.50%and 75.00%)(P<0.05).The incidence of adverse response in groups of B and C was lower than that in group A (12.50% and 10.00%vs.26.25%)(P<0.05).Conclusion The triple therapy combined with probiotics in the treatment of Hp infection can obviously reduce the incidence of adverse responses.The application of Saccharomyces boulardii sachets can enhance the eradication rate of Hp during triple therapy.

关 键 词：幽门螺杆菌 三联疗法 益生菌 儿童 

分 类 号：R573[医药卫生—消化系统]