性别和年龄对初诊1级原发性高血压患者实验室指标的影响研究  

Effect of gender and age on laboratory parameters in stage 1 primary hypertension patients

作　　者：刘颖[1] 诸国华[2] 刘颜 华琦[2] Liu Ying;Zhu Guohua;Liu Yan;Hua Qi(Teaching and Research Section of Diagnostics ,Zunyi Medical College Zhuhai Campus,Zhuhai 519041,Guangdong Province,China)

机构地区：[1]遵义医学院珠海校区诊断学教研室,519041 [2]首都医科大学宣武医院心内科 [3]大庆医学高等专科学校过敏病医院内科

出　　处：《中华老年心脑血管病杂志》2018年第12期1282-1285,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨性别及年龄对初诊1级原发性高血压患者实验室指标的影响。方法选择2016年1～12月首都医科大学宣武医院确诊的1级原发性高血压患者159例,其中男性组71例,女性组88例。所有患者又根据年龄分为老年组40例(年龄≥60岁),男性14例,女性26例;中年组70例(45岁≤年龄<60岁),男性24例,女性46例;青年组49例(18岁≤年龄<45岁),男性33例,女性16例。收集24h收缩压、24h舒张压、空腹血糖、TC、TG、HDL-C、LDL-C、同型半胱氨酸(Hcy)、肌酐、尿酸、丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)等实验室指标。结果男性组Hcy、尿酸、ALT、AST、肌酐、TG水平明显高于女性组,发病年龄、HDL-C水平明显低于女性组,差异有统计学意义(P<0.05,P<0.01)。不同年龄男性和女性24h收缩压、24h舒张压比较,差异无统计学意义(P>0.05)。老年组、中年组和青年组男性患病比例分别占35.0%、34.3%和67.3%,女性患病比例分别占65.0%、65.7%和32.7%。老年组、中年组女性患病比例明显多于青年组,男性患病比例明显低于青年组,差异有统计学意义(P<0.01)。老年组男性肌酐和尿酸水平明显高于女性,差异有统计学意义(P<0.01)。中年组男性Hcy、肌酐、ALT、AST、尿酸、TG水平明显高于女性,HDL-C水平明显低于女性,差异有统计学意义(P<0.01)。青年组男性肌酐、ALT、AST、尿酸、TG水平明显高于女性,HDL-C水平明显低于女性,差异有统计学意义(P<0.05,P<0.01)。结论初诊1级原发性高血压老年患者女性居多。实验室指标存在性别差异,随年龄增大,性别差异减小。Objective To study the effect of gender and age on laboratory parameters in stage 1primary hypertension patients.Methods One hundred and fifty-nine stage 1primary hypertension patients admitted to our hospital were divided into male patients group (n=71)and female patients group (n=88)according their gender and into ≥60years old group (n=40),<60years old group (n=70)and <45years old group (n=49)according to their age.Their 24h SBP and DBP, serum levels of FPG,TC,TG,HDL-C,LDL-C,Hcy,creatinine,UA,ALT and AST were measured.Rusults The serum levels of Hcy,UA,ALT,AST,creatinine and TG were significantly higher while the age was significantly younger and the serum HDL-C level was significantly lower in male patients group than in female patients group (P<0.05,P<0.01)with no significant difference found in 24h SBP and DBP between the two groups (P>0.05).The incidence of stage 1primary hypertension was 35.0%,34.3%,67.3%respectively in ≥60years old group,<60 years old group,<45years old group,was 65.0%,65.7%,32.7%respectively in female patients of the 3groups,and was significantly lower in female patients of ≥60years old group and <60years old group than in male patients of <45years old group (P<0.01).The serum levels of creatinine and UA were significantly higher in female patients than in male patients of 960years old group (P<0.01).The serum levels of Hey,ereatinine,ALT,AST,UA and TG were significantly higher while the serum HDL-C level was signifieantly lower in male patients than in female patients of <60years old group and <45years old group (P<0.05,P<0.01).Conclusion The incidence of stage 1primary hypertension is higher in elderly female patients than in elderly male pastients.The laboratory parameters increase with age and decresease with gender.

关 键 词：高血压 性别因素 年龄因素 高半胱氨酸 尿酸 

分 类 号：R544.11[医药卫生—心血管疾病]