H型高血压患者的脑梗死风险与乙醛脱氢酶2基因多态性的相关性  

Correlation between cerebral infarction risk and aldehyde dehydrogenase 2 gene polymorphisms in patients with type-H hypertension

作　　者：刘春苗[1] 杨国帅[1] 刘炫君[1] 余丹[1] LIU Chunmiao;YANG Guoshuai;LIU Xuanjun;YU Dan(Department of Neurology,Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou,Hainan 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院神经内科

出　　处：《中国热带医学》2018年第12期1251-1254,1268,共5页China Tropical Medicine

基　　金：海南省卫生厅资助项目(No.18A200035)

摘　　要：目的研究H型高血压患者的脑梗死风险与乙醛脱氢酶2(ALDH2)基因多态性的相关性,旨在对H型高血压患者脑梗死程度的评估、预后及治疗提供依据。方法选取海口市人民医院神经内科2017年10月-2018年3月收治的150例H型高血压患者,根据患者是否出现脑梗死将其分为脑梗死组和非脑梗死组。应用芯片杂交法对这150例患者行ALDH2基因检测。采用单因素分析及多因素Logistic回归分析模型筛选出脑梗死的危险因素。结果 150例H型高血压患者中出现脑梗死者93例(62.0%),未出现脑梗死者57例(38.0%)。ALDH2基因检测结果分为3型,分别为GG型、GA型、AA型。其中脑梗死组中GG型66例、GA型20例、AA型7例;非脑梗死组GG型50例、GA型4例、AA型3例。脑梗死组ALDH2基因AA/GA型的频率分布高于非脑梗死组(P<0.05),脑梗死组A等位基因的频率分布高于非脑梗死组(P<0.05)。单因素分析显示,脑梗死组和非脑梗死组在饮酒、高脂血症、糖尿病及A等位基因等方面差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,饮酒、高脂血症、糖尿病及A等位基因是脑梗死的危险因素。结论 H型高血压脑梗死的风险与乙醛脱氢酶2基因多态性有关,乙醛脱氢酶等位基因增加了H型高血压脑梗死的危险。Objective To research the correlation between cerebral infarction risk and aldehyde dehydrogenase 2 gene polymorphisms in patients with type-H hypertension, in order to provide basis for the degree evaluation, prognosis, and treatment of the cerebral infarction of patients with hypertension.Methods Totally 150 H-type hypertension patients admitted and treated in Neurology Department of Haikou People’s Hospital were selected from October 2017 to March 2018,and divided into cerebral infarction group and non cerebral infarction group according to whether patients with cerebral infarction. Chip hybridization was applied to ALDH2 gene detection in 150 patients. Univariate analysis and multivariate Logistic regression analysis model were performed to screen for all clinical indicators that may affect the occurrence of cerebral infarction in type-H hypertension patients.Results There were 93 cases of cerebral infarction(62.0%) and 57 cases(38.0%)without cerebral infarction in the 150 patients with H-type hypertension. There were 3 types by ALDH2 gene detection results which were GG type, GA type and AA type. Among the patients, there were 66 cases of GG type, 20 cases of GA type and 7 cases of AA type in cerebral infarction group, and 50 cases of GG type, 4 cases of GA type and 3 cases of AA type in non cerebral infarction group. The frequency distribution of AA/GA ALDH2 gene type in cerebral infarction group was higher than that in non cerebral infarction group(P<0.05). The frequency of A allelic gene in cerebral infarction group was higher than thatin non cerebral infarction group(P<0.05). Univariate analysis showed that there were significant differences in alcohol,hyperlipidemia, diabetes, and A allelic between the cerebral infarction group and the non-cerebral infarction group(P<0.05).Multivariate Logistic regression analysis showed that alcohol, hyperlipidemia, diabetes and A allelic were risk factors forcerebral infarction.Conclusion The risk of type-H hypertension cerebral infarction is related to the gene pol

关 键 词：H型高血压 脑梗死 乙醇脱氢酶2 

分 类 号：R743.2[医药卫生—神经病学与精神病学]