基于脊髓内功能电激励的大鼠后肢运动选择性控制  

Selective control of hindlimb movements based on intraspinal functional electronic stimulation

作　　者：沈晓燕[1] 王志功[2] 马磊[1] 吕晓迎[3] 杜薇[1] 陈轶[4] 陶春伶 SHEN Xiaoyan;WANG Zhigong;MA Lei;LU Xiaoying;DU Wei;CHEN Yi;TAO Chunling(School of Electronic Information,Nantong University,Nantong,Jiangsu 226019,P.R.China;Institute of RF-&OE-ICs,Southeast University,Nanjing 210096,P.R.China;State Key Lab of Bioelectronics,Southeast University,Nanjing 210096,P.R.China;School of Medical Information,Nantong University,Nantong,Jiangsu 226019,P.R.China)

机构地区：[1]南通大学电子信息学院,江苏南通226019 [2]东南大学射频与光电集成电路研究所,南京210096 [3]东南大学生物电子学国家重点实验室,南京210096 [4]南通大学医学院,江苏南通226019

出　　处：《生物医学工程学杂志》2018年第6期860-863,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金面上项目(81371663);国家自然科学基金重点项目(61534003);江苏省研究生科研与实践创新计划项目(KYCX18_2424)

摘　　要：脊髓内功能电激励提供了一种恢复脊髓损伤患者运动功能的途径。本研究的目标是在大鼠脊髓上确定诱发后肢不同动作的区域,对支配相应动作的区域进行归一化描述,并验证脊髓内功能电激励能够用于后肢运动功能恢复。实验中利用了三维扫描式功能电激励技术对大鼠脊髓腰骶段进行刺激。结果表明,对腰骶段脊髓腹侧进行电刺激能够产生单关节或多关节的协调运动,合理选择刺激位点能够诱发后肢多种不同动作,且后肢运动向量图覆盖后肢运动的矢状平面的各个方向。本文绘制了大鼠脊髓运动功能图谱,对相关动作的控制区域进行归一化描述,为后续实验中电极植入位点的确定提供指导。Functional electronic stimulation (FES)may provide a means to restore motor function in patients with spinal cord injuries.The goal of this study is to determine the regions in the spinal cord controlling different hindlimb movements in the rats.Normalization was used for the regions dominating the corresponding movements.It has been verified that FES can be used in motor function recovery of the hindlimb.The spinal cord was stimulated by FES with a three-dimensional scan mode in experiments.The results show that stimulation through the electrodes implanted in the ventral locations of the lumbosacral enlargement can produce coordinated single-and multi-joint hindlimb movements.A variety of different hindlimb movements can be induced with the appropriate stimulation sites,and movement vectors of the hindlimb cover the full range of movement directions in the sagittal plane of the hindlimb.This article drew a map about spinal cord motor function of the rat.The regions in the spinal cord which control corresponding movements are normalized.The data in the study provide guidance about the location of electrode tips in the follow-up experiments.

关 键 词：功能电激励 运动控制 脊髓损伤 

分 类 号：R651.2[医药卫生—外科学]