苦参碱注射液对宫颈癌患者化疗增敏作用和生存质量、免疫功能的影响  

Effect of Matrine Injection on Chemosensitivity, Quality of Life and Immune Function in Patients with Cervical Cancer

作　　者：杜锐[1] 张莹莹[1] 户庆峰[2] DU Rui;ZHANG Yingying;HU Qingfeng(Shangqiu Medical College,Shangqiu 476100,Henan,China;Department of oneology,Shangqiu First People's Hospital,Shangqiu 476100,Henan,China)

机构地区：[1]商丘医学高等专科学校,河南商丘476100 [2]商丘市第一人民医院肿瘤科,河南商丘476100

出　　处：《中华中医药学刊》2018年第12期3051-3055,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省教育厅科学技术研究重点项目(14B320011);河南省社科联、河南省经团联调研项目(SKL-2017-2107);商丘市科技发展计划项目(131146)

摘　　要：目的:探讨苦参碱注射液对宫颈癌患者化疗增敏作用和生存质量、免疫功能的影响。方法:选取2016年3月-2017年5月收治医院的70例宫颈癌患者,按照随机数字表法随机分成对照组和观察组,每组35例。对照组患者采用顺铂联合多西他赛化疗方案进行治疗,而观察组患者在采用顺铂联合多西他赛化疗方案进行治疗治疗的基础上,联合予以苦参碱注射液进行治疗。干预治疗12周后,分别对两组患者的临床疗效、增敏作用、免疫功能、生活质量以及不良反应发生情况进行比较。结果:①观察组患者的总治疗有效率为94.29%,显著高于对照组患者的总治疗有效率71.43%,差异有统计学意义(χ2=4.928,P=0.026);②干预治疗后,两组患者的血清CA125水平、IL-6水平均较干预治疗前明显降低(t=9.364,27.737,2.826,8.067;均P<0.05),且观察组患者的降低水平更明显(t=25.469,4.951;均P<0.05);两组患者的血清IL-18、IFN-γ水平均较干预治疗前明显升高(t=-5.681,-13.721,-15.960,-14.464;均P<0.01),其观察组患者的升高水平更显著,差异有统计学意义(t=-7.560,-8.563;均P<0.01);③对照组患者的血清CD+3、CD+4、CD+8水平较干预治疗前降低,CD+4/CD+8较治疗前升高(t=5.245,4.019,9.400,3.101;均P<0.05);而观察组患者CD+3、CD+4、CD+8水平较干预治疗前显著升高,CD+4/CD+8较治疗前降低(t=-6.742,-14.260,-2.681,-10.205;均P<0.05);干预治疗后两组患者CD+3、CD+4、CD+8以及CD+4/CD+8水平比较差异均存在统计学意义(t=-11.688,-19.981,-10.908,-11.673;均P<0.05);④干预质量后两组患者的QOL评分以及KPS评分均较干预治疗前显著改善(t=-7.514,-16.664,-3.355,-7.328;均P<0.05),且观察组患者改善的情况显著优于对照组患者,差异均存在统计学意义(t=-8.773,-3.928;均P<0.05);⑤观察组患者的不良反应发生情况显著优于对照组患者(χ2=4.690,4.629,4.644,7.295;P=0.030,0.031,0.031,0.007)。结论:采用苦参碱注射液用于宫颈癌化�Objective:To explore the effect of Matrine Injection on chemosensitivity,quality of life and immune function in patients with cervical cancer.Method :Seventy cases of cervical cancer in our hospital were admitted to our hospital in March 2016to May 2016.The patients were randomly divided into the control group and the observation group according to the random number table method,with 35cases in each group.The control group was treated with cisplatin plus docetaxel chemotherapy,while the observation group was treated with cisplatin combined with docetaxel chemotherapy. The treatment was combined with Matrine Injection.After 12 weeks of intervention,the clinical efficacy,sensitization, immune function,quality of life and the incidence of adverse reactions were compared in the two groups.Results:①The total effective rate of the patients in the observation group was 94.29%,which was significantly higher than that of the control group.The total effective rate was 71.43%,and the difference was statistically significant (χ^2=4.928,P = 0.026).②After intervention,the two groups'serum CA125 level and IL-6level were significantly decreased(t = 9.364,27.737,2.826,8.067;P <0.05),and the patients in the observation group's decreased more obviously (t=- 25.469,4.951;P <0.05).The two groups'serum IL -18and IFN -γ levels were significantly increased (t =--5.681,-13.721,-15.960,-14.464;P <0.01 ).The observation group's were significantly elevated and the difference was statistically significant(t =-7.560,-8.563;P <0.01).③The control group's serum levels of CD3^+, CD4^+ and CD8^+ were reduced after treatment and CD4+/CD^+higher than that before treatment(t =5.245,4.019,9.400, 3.101;P <0.05)and the observation group's CD3^+,CD4^+,CD8^+levels were significantly increased and CD4+/CD8+ was decreased(t =-6.742,-14.260,-2.681,-10.205P <0.05).After intervention,the two groups'CD3^+, CD4^+,CD8^+and CD4^+/CD8^+ differences were statistically significant(t =-11.688,-19.981,-10.908,-11.673; P<0.05).④The two groups'QOL score and KPS

关 键 词：宫颈癌 化疗 增敏 苦参碱注射液 免疫功能 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤] R453[医药卫生—临床医学]