氮杂环卡宾催化芳香醛的氧化酯化反应（英文）  

N-Heterocyclic Carbene-Catalyzed Oxidative Esterification of Aldehydes:Facile Access to α-Acyloxyacetates and Cyanomethyl Esters

作　　者：巨磊 马春梅 唐蜜 王妍卉 虞心红[1] 马红梅[1] Ju Lei;Ma Chunmei;TangMi;Wang Yanhui;Yu Xinhong;Ma Hongmei(Shanghai Key Laboratory of New Drug Design,State Key Laboratory Of Bioengineering Reactors,School of Pharmacy,East China University of Science &Technology,,Shanghai200237)

机构地区：[1]上海市新药设计重点实验室生物反应器工程国家重点实验室华东理工大学药学院制药工程系,上海200237

出　　处：《有机化学》2018年第11期3056-3062,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.20972051,21476078);the Science and Technology Commission of Shanghai Municipality(Nos.12431900900,12431900902,08431901800,08430703900)~~

摘　　要：报道了一种基于氮杂环卡宾催化的醛与溴乙酸乙酯或溴乙腈的氧化酯化反应.该策略无需过渡金属催化剂参与,能够在温和的反应条件下以较高收率合成α-酰氧基羧酸酯和氰甲基羧酸酯类化合物.An efficient N-heterocyclic carbene-catalyzed oxidative esterification reaction of aldehydes with ethyl bromoacetate or bromoacetonitrile has been explored.This transition metal-free protocol allows access to a wide variety of α-acyloxyacetates and cyanomethyl esters in good to excellent yields under mild reaction condition.

关 键 词：卡宾 醛 酯化 氧化 有机催化 

分 类 号：O621.251[理学—有机化学]