PGF2α对大鼠肌筋膜疼痛触发点自发肌电活动的影响  

Effects of PGF2α on spontaneous electrical activity of myofascial trigger points in rats

作　　者：李丽辉 薄成志 黄强民 刘庆广 刘琳[2] 马彦韬 赵佳敏 LI Lihui;BO Chengzhi;HUANG Qiangmin(Department of Sport Medicine and the Center of Rehabilitation,School of Kinesiology,Shanghai University of Sport,Shanghai,200438)

机构地区：[1]上海体育学院运动科学学院运动康复学系,上海200438 [2]南京体育学院运动健康科学系

出　　处：《中国康复医学杂志》2018年第12期1399-1404,共6页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金面上项目(81470105);教育部上海市人类运动能力开发与保障重点实验室(上海体育学院)支撑项目(11DZ2261100);运动健身科技省部共建教育部重点实验室(上海体育学院)支撑项目

摘　　要：目的:观察肌筋膜疼痛触发点(MTrPs)模型大鼠外周血中前列腺素F2α(PGF2α)浓度变化情况,并通过体外注射PGF2α观察其对触发点肌电活动的影响,探究PGF2α与触发点的关系。方法:40只雌性SD大鼠随机分为对照组(CG组)、造模组(MG组)、生理盐水组(SG组)和PGF2α组(PG组),每组10只。除CG组外,其余三组采取打击结合离心运动进行干预8周,恢复4周,检测受累肌结节、紧绷带、局部抽搐反应和自发性电位;CG组正常饲养12周。12周后ELISA法测量各组大鼠血清PGF2α浓度。之后分别对SG组局部肌肉注射生理盐水,PG组局部肌肉注射PGF2α,CG组和MG组分别作为空白对照和模型对照不注射任何物质。干预后即刻记录各组静息状态下的自发性电活动。结果:与CG组相比,其余三组大鼠血清PGF2α浓度均显著性增加(P<0.05)。给药后即刻,MG组、SG组和PG组大鼠均能记录到异常的自发电位,对照组大鼠基本无电活动,肌电波形形似一条直线。与CG组相比,MG组、SG组和PG组的肌电波频、波幅以及波长均有显著性差异(P<0.05);PG组显著高于MG组和SG组(P<0.05)。MG组和SG组之间相比各指标均无显著性差异。结论:PGF2α能增加触发点肌纤维的肌电活动,促使触发点活性增加。Objective: The aims of this study were to investigate the changes on spontaneous electrical activities (SEAs)and the levels of PGF2α in myofascial trigger points (MTrPs) in a rat model, and to find out the possible relationshipbetween MTrPs and PGF2α.Method: 40 female Sprague- Dawley rats were randomly divided into 4 groups, control group (CG), modelgroup (MG), saline group (SG) and PGF2α group (PG). Each group included 10 rats. MG/SG/PG received ablunt strike to the left vastus medialis combined with eccentric exercise for 8 weeks, then 4 weeks to restore.The rats in CG were fed normally without intervention for 12 weeks. The level of PGF2α was measured foreach group after modeling. Then intramuscular injection of normal saline and PGF2α each for SG and PG.The SEAs were recorded immediately after intervention in a resting state.Result: After modeling, the concentration of PGF2α in serum of model groups was significantly increasedwhen compared to control groups(P<0.05). Immediately after administration, the model groups could record anabnormal spontaneous potential,while only a horizontal baseline in blank control group. Compared to CG, thefrequencies, amplitude and wavelength of SEAs were significantly higher than that in MG/SG/PG(P<0.05). Comparedto PG, the frequencies, amplitude and wavelength of SEA were significantly higher than that in MG/SG(P<0.05). There was no significant difference between MG and SG.Conclusion: This study may further clarify that PGF2α could enhance the SEAs of myofiber in MTrPs, indicatingthat the PGF2α can increased the MrTPs fibres activity.

关 键 词：肌筋膜疼痛触发点 前列腺素F2Α 肌电图 原发性痛经 

分 类 号：R741.0[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]