miR-155在喉鳞癌中的表达及其临床意义  

Expression and significance of miR-155 in larngeal squamous cell carcinoma

作　　者：马志超[1] 江波[1] 陶宝鸿[1] 张朝晖[1] 金巧智[1] MA Zhi -chao;JIANG Bo;TAO Bao -hong;ZHANG Chao -hui;JIN Qiao -zhi(OtorhinolaryagoIogy Department,Taizhou Municipal Hospital,Taizhou ,Zhejiang 318000,China)

机构地区：[1]台州市立医院耳鼻咽喉科

出　　处：《中国卫生检验杂志》2018年第23期2879-2881,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨miR-155在喉鳞癌中的表达水平及其与临床分期、分化程度、淋巴转移及预后等临床病理参数的关系。方法用qRT-PCR检测miR-155在94例喉鳞癌组织(喉鳞癌组)和35例癌旁正常喉黏膜上皮组织(对照组)中的表达,分析其与临床病理学特征的关系。Kaplan-Meier法与Log-rank检验分析生存情况。结果 miR-155在喉鳞癌组和对照组的表达量平均值分别为4. 28±1. 65、1. 21±0. 32,其表达分别在不同的临床分期、T分期及淋巴转移之间差异有统计学意义(P <0. 05),而在性别、年龄、吸烟、分化程度及分型之间差异无统计学意义(P>0. 05),生存分析结果显示喉鳞癌患者miR-155高表达组比miR-155低表达组的生存时间更短,差异有统计学意义(P <0. 05)。结论 miR-155高表达可能是影响喉鳞癌预后的重要因素, miR-155可能是肿瘤生物轴重要的靶点,为喉鳞癌早期浸润的诊断和治疗提供新的实验依据。Objective To investigate the expression of miR-155 in laryngeal squanlous cell carcinoma( LSCC) and its relationship with the clinicopathologic features,such as clinical stage and lymph node metastasis. Methods The expression of miR-155 was detected by qRT-PCR in 94 cases of para-carcinoma normal tissues( LSCC group) and 35 cases of laryngeal mucosal epithelium( control group). The correlation of miR-155 expression with various clinicopathologic features was evaluated. Kaplan-Meier method and Log-rank test were used to analyze the survival rate. Results The expression of miR-155 in LSCC group and control group were 4. 28 ± 1. 65 and 1. 21 ± 0. 32. There was statistical significance on the differences in expressions between different clinical stages,T stages and lymphatic metastasis( P < 0. 05),but there was no significant difference in gender,age,smoking,differentiation and typing( P > 0. 05). The survival analysis showed that miR-155 high expression group had shorter survival time than the miR-155 low expression group,and the difference was statistically significant( P < 0. 05). Conclusion High expression of miR-155 may be an important factor affecting the prognosis of LSCC;miR-155 may be an important target for tumor biological axis,providing a new experimental basis for the diagnosis and treatment of early infiltration of LSCC.

关 键 词：MIR-155 喉鳞癌 预后 

分 类 号：R739.65[医药卫生—肿瘤]