Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice  

作　　者：Minbo Zang Qiao Zhou Yunfei Zhu Mingxi Liu Zuomin Zhou 

机构地区：[1]State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology,Nanjing Medical University

出　　处：《The Journal of Biomedical Research》2018年第6期442-453,共12页生物医学研究杂志（英文版）

摘　　要：Non-Hodgkin lymphoma(NHL) is one of the most common cancers affecting men of reproductive age. The high response rate of bendamustine as first-line treatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim was to determine the effects of bendamustine on male reproduction by animal model. Male mice were treated with bendamustine(40 mg/kg) through tail vein injection while cisplatin was given as a standard(3 mg/kg) through intraperitoneal injection. After 3 weeks, bendamustine induced weight loss and sperm morphology abnormalities were compared to the control. Additionally, sperm with folded tails were the most frequent abnormality in bendamustine-treated mice. But the mechanism of sperm abnormality induced by bendamustine remains to be elucidated. These results indicate bendamustine may affect spermatozoa of patients who have been treated for NHL.Non-Hodgkin lymphoma(NHL) is one of the most common cancers affecting men of reproductive age. The high response rate of bendamustine as first-line treatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim was to determine the effects of bendamustine on male reproduction by animal model. Male mice were treated with bendamustine(40 mg/kg) through tail vein injection while cisplatin was given as a standard(3 mg/kg) through intraperitoneal injection. After 3 weeks, bendamustine induced weight loss and sperm morphology abnormalities were compared to the control. Additionally, sperm with folded tails were the most frequent abnormality in bendamustine-treated mice. But the mechanism of sperm abnormality induced by bendamustine remains to be elucidated. These results indicate bendamustine may affect spermatozoa of patients who have been treated for NHL.

关 键 词：Non-Hodgkin lymphoma CHEMOTHERAPY BENDAMUSTINE MICE SPERMATOZOA TOXICOLOGY 

分 类 号：R733[医药卫生—肿瘤]