2型糖尿病合并戊型肝炎患者的临床特征分析  

Clinical characteristics of type 2 diabetes complicated with hepatitis E

作　　者：张祎昀[1] 徐雷[1] 唐兆生[1] 陈英华[1] 窦琴[2] 冯波[1] ZHANG Yiyun;XU Lei;TANG Zhaoshen;CHEN Yinghua;DOU Qin;FENG Bo(Department of Endocrinology,Shanghai East Hospital,Tongji University school of Medicine,Shanghai 200123,China;Department of Clinicle Laoratory,Shanghai East Hospital,Tongji University school of Medicine,Shanghai 200123,China)

机构地区：[1]同济大学附属东方医院内分泌科,上海200123 [2]同济大学附属东方医院检验科,上海200123

出　　处：《诊断学理论与实践》2018年第5期557-561,共5页Journal of Diagnostics Concepts & Practice

基　　金：上海市浦东新区卫生系统重点专科建设计划资助(PWZzk2017-12)

摘　　要：目的:探讨2型糖尿病合并戊型肝炎患者的临床特征。方法 :回顾性分析119例2型糖尿病合并戊型肝炎患者的性别、年龄等临床特征,另设无肝炎的2型糖尿病组(单纯糖尿病组)及单纯戊型肝炎组患者作为对照,比较3组的实验室检查结果。结果:2型糖尿病合并戊型肝炎组中,50~69岁年龄段的患病人数较多(占65%)。2型糖尿病合并戊型肝炎组患者的糖化血红蛋白(hemoglobinA1c, HbA1C)水平低于单纯糖尿病组患者[(8.0±1.8)%比(8.4±2.0)%](P<0.01),但2组间比较空腹血糖及餐后血糖差异无统计学意义(P>0.05);2型糖尿病合并戊型肝炎组的总胆红素及天冬氨酸转氨酶明显低于单纯戊型肝炎组(P<0.05);单纯糖尿病组、单纯戊型肝炎组、2型糖尿病合并戊型肝炎组这3组间比较的肾功能、血脂指标差异均无统计学意义(P>0.05)。结论:2型糖尿病合并戊型肝炎患者的HbA1c低于单纯糖尿病患者,其余血糖指标没有差异;与单纯戊型肝炎组患者相比,2型糖尿病合并戊型肝炎组患者的肝功能并没有出现进一步的减退。Objective:To study the clinical characteristics of type 2diabetes mellitus complicated with hepatitis E. Methods:The clinical characteristics of 119type 2diabetes patients complicated with hepatitis E were retrospectively analyzed.The results were compared with type 2diabetes patients without hepatitis E (simpletype 2diabetes mellitus)and with simple hepatitis E patients.Results:The number of patients between 50-69years of age was higher in type 2diabetes complicated with hepatitis E group (65%).HbA1C was lower than that in simple type 2diabetes group(P<0.01).There were no statistical significant differences between the two groups in fasting and postprandial blood glucose (P>0.05).Compared with simple hepatitis E group,total bilirubin and AST were lower in type 2diabetes patients complicated with hepatitis E (P< 0.05).There were no significant differences in renal function and blood lipid indexes between these three groups.Conclusions:HbA1C in type 2diabetes patients complicated with hepatitis E was lower than that in patients with type 2diabetes alone.Thereare no significant differences in other blood glucose indice.Compared with simple hepatitis E patients,there was no further decline in liver function in type 2diabetes patients complicated with hepatitis E.The three groups had no signif- icant differences in renal function and blood lipid indice.

关 键 词：2型糖尿病 戊型肝炎 戊型肝炎病毒 临床特征 

分 类 号：R575.1[医药卫生—消化系统]