维生素D影响自噬的作用机制研究进展  

Advances in the mechanism of vitamin D affecting autophagy

作　　者：刘蕾 李景辉[1] 邓超[1] 陈丹丹[1] Liu Lei;Li Jinghui;Deng Chao;Chen Dan dan(Department of Intensive Care Unit,Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou 570208,Hainan,China)

机构地区：[1]中南大学湘雅医学院附属海口医院重症医学科,海南海口570208

出　　处：《中华危重病急救医学》2018年第11期1103-1106,共4页Chinese Critical Care Medicine

基　　金：海南省海口市重大科技创新项目(2015-034).

摘　　要：自噬广泛存在于真核细胞中,是一种细胞降解过程,对人体健康有至关重要的作用,自噬调控失衡会导致多种疾病发生。目前研究已表明,维生素D在诱导、成核、延伸至成熟和降解等不同水平上均能调节自噬,从而影响疾病发生发展,但其作用机制鲜见系统阐述。深入了解维生素D调节自噬的机制有助于指导相关疾病的诊治,故本文就维生素D对自噬调节的作用机制进行综述,为指导基础及临床研究实践提供理论依据。Autophagy is a degradative process of eukaryotic cell,which plays a vital role in human health. Autophagy imbalance is associated with many diseases.It has been reported that vitamin D can regulate the autophagy in different levels,including induction,nucleation,as well as elongation to maturation and degradation,which affects the occurrence and development of the disease.However,its action mechanism has not been systematically elaborated,and a deeper understanding of the mechanism of vitamin D-regulated autophagy is helpful to guide the diagnosis and treatment of related diseases.The review described the mechanism of vitamin D affecting autophagy to provide theoretical basis for guiding basic and clinical research.

关 键 词：维生素D 自噬 炎症反应 

分 类 号：R363[医药卫生—病理学]