扩散张量成像在大脑胶质瘤交叉性小脑神经机能联系不能的应用  

Application of diffusion tensor imaging in crossed cerebellar diaschisis of cerebral gliomas

作　　者：黎美 肖新兰[1] 黄江龙[1] 钱斌燕 LI Mei;XIAO Xinlan;HUANG Jianglong;QIAN Binyan(Imaging Center,the Second Affiliated Hospital of Nanchang University ,Nanchang330000,China)

机构地区：[1]南昌大学第二附属医院影像中心,江西南昌330000

出　　处：《实用放射学杂志》2018年第12期1839-1841,共3页Journal of Practical Radiology

摘　　要：目的探讨扩散张量成像(DTI)在大脑胶质瘤交叉性小脑神经机能联系不能(CCD)中的应用。方法回顾性分析经术后病理证实的17例大脑高级别胶质瘤患者和20例低级别胶质瘤患者与18例正常志愿者的MR图像,利用DTI技术定量测量小脑半球的部分各向异性分数(FA),计算并比较患者小脑半球不对称指数(AI),并分析CCD现象与大脑胶质瘤肿瘤病理级别的关系。结果大脑高级别胶质瘤患者肿瘤对侧小脑半球的FA值较同侧小脑半球降低(t=3.42,P<O.05)。大脑低级别胶质瘤患者肿瘤对侧小脑半球与同侧小脑半球的FA值差异无统计学意义(t=0.80,P>0.05)。高级别胶质瘤患者m小脑较低级别胶质瘤患者和正常志愿者Ah、目均增高t=4.15,P<O.05;t=4.68,P<O.05),而低级别胶质瘤患者与正常志愿者AI小脑目的差异无统计学意义(t=0.79,P>O.05)。结论大脑胶质瘤的CCD现象与胶质瘤的病理级别相关,高级别胶质瘤患者可出现CCD现象,而低级别胶质瘤患者未发现明显CCD现象。DTI技术可通过FA参数无创定量评估CCD。Objective To explore the application of diffusion tensor imaging (DTI)in crossed cerebellar diaschisis (CCD)of cerebral gliomas. Methods MR images of 17patients with high grade gliomas and 20patients with low grade gliomas confirmed by postoperative pathology and 18normal controls were analyzed retrospectively.The fractional anisotropy (FA)of cerebellar hemisphere was quantitatively measured with DTI technique.The asymmetry index (AI)of cerebellar hemispheric was calculated and compared in patients.The correlation between CCD phenomenon and histological grade of cerebral gliomas was also analyzed.Results Compared with ipsilateral cerebellar hemisphere of cerebral high grade gliomas,the FA value of contralaterai cerebellar hemisphere significantly reduced (t =3.42,P<0.05).But there were no significant differences of FA values between contralateral cerebellar hemisphere and ipsilateral cerebellar hemisphere in cerebral low grade gliomas patients (t =0.80,P>0.05).The AI values of cerebellar hemisphere in high grade gliomas increased compared with low grade gliomas and normal controls (t =4.15,P <0.05;t =4.68,P<0.05),but there were no significant differences in the AI values of c erebellar hemisphere between low grade gliomas patients and normal controls (t =0.79,P >0.05).Conclusion CCD phenomenon is associated with the histological grade of cerebral gliomas.High grade gliomas can cause CCD phenomenon,but there is no evident CCD phenomenon in low grade gliomas.DTI technique is able to quantitatively assess CCD noninvasively by FA parameter.

关 键 词：交叉性小脑神经机能联系不能 胶质瘤 扩散张量成像 

分 类 号：R742.82[医药卫生—神经病学与精神病学] R739.41[医药卫生—临床医学]