表观扩散系数值测量对子宫内膜癌组织学分级和肌层浸润深度的评估价值  

ADC measurement in assessment of tumor grade and myometrial invasion of endometrial carcinoma

作　　者：刘佳 王士甲 张国福 马凤华 田晓梅 王冬燕 张燕玉 谷守欣 邬敏婕 LIU Jia;WANG Shijia;ZHANG Guofu;MA Fenghua;TIAN Xiaomei;WANG Dongyan;ZHANG Yanyu;GU Shouxin;WU Minjie(Department of Radiology,the Affiliated Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院放射科,上海200090

出　　处：《实用放射学杂志》2018年第12期1893-1897,共5页Journal of Practical Radiology

摘　　要：目的探讨子宫内膜癌(EC)表观扩散系数(ADC)测量对组织学分级和肌层浸润深度的评估价值。方法回顾性分析行1.5T常规MRI和扩散加权成像(DWI)(b=0,1000s/mm。)检查的EC患者和术后病理证实具有正常子宫内膜的宫颈癌患者共108例。2名放射科医师对2组患者的子宫内膜进行ADC值测量。统计学分析采用SPSS19.0和Medcalc软件进行。结果EC组GI^G3ADC值(×10-3mm2/s)分别为O.851±O.131,0.752±O.099,0.681士O.089,组间平均ADC值均有显著统计学差异(G1VSG2:P=O.005;G2VSG3:P=0.03;G1VSG3:P<O.0001)。当平均ADC值≤O.742×10-3mm2/s时,对于G3的诊断灵敏度、特异性和准确性分别为88.24%、76.19%和85%,曲线下面积为O.851。结论EC组织学分级之间平均ADC值有显著统计学差异。ADC值测量可能具有术前初步筛选G3的潜能。Objective To investigate the value of the apparent diffusion coefficient (ADC)measurement in assessment of tumor grade and myometrial invasion of endometrial carcinoma (EC).Methods 80EC patients and 28cervical cancer patients with normal endometrium were studied retrospectively.l.ST conventional MRI and DWI (b=0,1000s/mm2)were performed,and ADC values were calculated by two radiologists.Statistical analyses were performed by using SPSS 19.0and Medcalc software.Results The mean ADC values (× 10^-3mm^2/s)were 0.851±0.131,0.752±0.099,0.681±0.089for G1,G2and G3EC,respectively.Significant statistical differences were achieved for the three groups (G1vs G2:P =0.005;G2vs G3:P =0.03;G1vs G3:P <0.0001).For the prediction of G3,the area under the curve (AUC)of 0.851and the cut-off value of ≤0.742×10^-3mm^2/s were identified,with the sensitivity, specificity and accuracy of 88.24%,76.19%and 85M,respectively.Conclusion There are significant statistical differences between histologic grades of EC.ADC measurement may have the potential to select G3EC patients.

关 键 词：子宫内膜癌 磁共振成像 扩散加权成像 表观扩散系数 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]