呼吸导航IDEAL-IQ在肝脏脂肪定量中的应用:与磁共振波谱对比研究  

Application of navigator IDEAL-IQ in liver fat quantification:a comparative study with MRS

作　　者：江广斌 胡必富 苏大军 叶晓 张楚 菅志远 JIANG Guangbin;HU Bifu;SU Dajun;YE Xiao;ZHANG Chu;JIAN Zhiyuan(Department of Radiology,Suizhou Hospital,Hubei University of Medicine,Suizhou Central Hospital ,Suizhou441300,China;Department of Gastrointestinal Surgery,the Affiliated Hospital of Guilin Medical University,Guilin 541000,China)

机构地区：[1]湖北医药学院附属随州医院随州市中心医院医学影像科,湖北随州441300 [2]广西桂林医学院附属医院胃肠外科,广西桂林541000

出　　处：《实用放射学杂志》2018年第12期1937-1940,1948,共5页Journal of Practical Radiology

基　　金：湖北省教育厅重点项目(D20162102);湖北省卫生和计划生育委员会青年人才项目(WJ2015Q041).

摘　　要：目的采用呼吸导航脂肪定量序列(NavIDEAL-IQ)进行脂肪定量,并与传统屏气IDEAL-IQ及磁共振波谱(MRS)的定量结果进行对比。方法纳入20例正常志愿者、20例脂肪肝及20例其他肝脏病变患者,进行IDEAL-IQ、NavIDEAL-IQ和MRS成像,分别测量3种方法获得的脂肪分数。使用t检验两两对比测量结果是否存在差异,并采用spearman彻相关分析检验其相关性。结果IDEAL-IQ对正常志愿者、脂肪肝、其他肝脏病变肝脏脂肪定量的结果分别为(4.09±O.82)%,(15.5±6.1)%和(4.20±O.84)%,NavIDEAL-IQ对正常志愿者、脂肪肝、其他肝脏病变肝脏脂肪定量的结果分别为(3.94±O.83)%,(11.8±6.5)%和(4.00±O.94)%,而MRS对正常志愿者、脂肪肝、其他肝脏病变肝脏脂肪定量的结果分别为(3.92±O.85)%,(12.4±7.2)%和(3.97±O.96)%,3组对比均无显著差异(P>O.05)。3个受试组IDEAL-IQ与MRS脂肪定量的结果均有显著正相关性,相关系数分别为O.959,O.786和O.945。结论呼吸导航IDEAL-IQ脂肪定量结果和传统屏气IDEAL-IQ及MRS一致,同时提高了脂肪定量检查的成功率,是一种无创、方便、准确测量脂肪分数的方法。Objective To quantitatively assess the liver fat content by Nav IDEAL-IQ and compare with conventional breath-hold IDEAL-IQ and magnetic resonance spectroscopy (MRSI.Methods Twenty volunteers,twenty fatty liver patients and twenty patients with other liver diseases were enrolled in this study.IDEAL-IQ,Nav IDEAL-IQ and MRS imaging were performed and fat fraction (FF) were measured respectively.The results were compared by t-test to explore whether there were differences between these groups. Spearman correlation analysis was also used to test the correlatiorLResults No significant differences in the FF measured by IDEAL-IQ,Nav IDEAL-IQ and MRS in normal volunteers [(4.09±0.82)%,(3.94±0.83)%,(3.92±0.85)%],fatty liver [(15.5±6.1)%,(11.8±6.5)%,(12.4±7.2)%] and other liver lesions patients [(4.20±0.84)%,(4.00±0.94)%,(3.97±0.96)%]were found between these groups [P >0.05). There was a significant positive correlation between Nay IDEAL-IQ and MRS,and the correlation coefficients of these groups were 0.959,0.786 and 0.945,respectively.Conclusion The results of Nay IDEAL-IQ of fat quantification are consistent with MRS results and it increases the success rate of fat quantitative testing.In a word,it is a noninvasive,convenient and accurate way to measure fat fraction.

关 键 词：非酒精性脂肪性肝病 磁共振波谱 呼吸导航水脂分离成像 肝脏脂肪分数定量 

分 类 号：R575[医药卫生—消化系统] R445.2[医药卫生—内科学]