超声微泡携基因治疗肝脏疾病应用进展  

Application progresses of ultrasound microbubbles carrying gene in treatment of liver diseases

作　　者：席佳达 夏国园[1] 程祖胜 XI Jiada;XIA Guoyuan;CHENG Zusheng(College of Medicine,Shaoxing University,Shaoxing 312000,China;Department of Radiology,Shaoxing Seventh People's Hospital,Shaoxing 312000,China)

机构地区：[1]绍兴文理学院医学院,浙江绍兴312000 [2]绍兴市第七人民医院放射科,浙江绍兴312000

出　　处：《中国医学影像技术》2018年第12期1897-1900,共4页Chinese Journal of Medical Imaging Technology

基　　金：浙江省自然科学基金(Y2110966);浙江省医药卫生研究计划项目A类(2015RYA225);浙江省公益性技术应用研究计划项目(2014C33152)

摘　　要：超声靶向微泡破坏技术通过空化效应有效促进外源基因在目的组织中的转染,可通过抑制细胞某些基因的表达或抑制其信号通路而进行基因治疗,使基因治疗各类肝脏疾病逐渐成为可能。本文主要就超声微泡携基因在肝脏疾病中的应用进展进行综述。Ultrasound-targeted microbubbles destruction can effectively promote transfection of the exogenous gene in target tissue with the cavitation,and inhibit the expression of some genes of cells or inhibit their signaling pathways, thereby achieving the purpose of gene therapy and making the treatment of various liver diseases gradually become possible. The application progresses of ultrasound microbubbles carrying genes in treatment of liver diseases were reviewed in this article.

关 键 词：微泡 造影剂 基因 超声检查 肝 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]