多发性骨髓瘤患者^18F-FDG PET/CT显像分析  

Imaging analysis of ^18F-FDG PET/CT in patients with multiple myeloma

作　　者：李现军[1] 李凤岐[1] 李桂芝[1] 赵志华[1] 宋振国[1] Li Xianjun;Li Fengqi;Li Guizhi;Zhao Zhihua;Song Zhenguo(Department of Nuclear Medicine,Weifang People's Hospital,Weifang 261041,China)

机构地区：[1]山东省潍坊市人民医院核医学科,261041

出　　处：《中华核医学与分子影像杂志》2018年第12期790-792,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：潍坊市卫生科技发展计划项目(2016WSJS112).

摘　　要：目的分析多发性骨髓瘤(MM)患者18F-脱氧葡萄糖(FDG)PET/CT显像的特征。方法回顾性分析2011年1月至2016年8月间经病理证实的68例MM患者[男41例,女27例;年龄(61.5±17.2)岁],分析其PET/CT图像,测定病灶最大标准摄取值(SUVmax),统计病变累及范围评分(将全身骨骼分为10类,累及1类计为1分,累及2类计为2分,以此类推)、骨病灶数量、骨破坏周围是否合并软组织肿物等。结果MM患者病灶SUVmax差异较大,68例共检出病灶1310个,呈轻度代谢升高(2.5≤SUVmax<5.0)的病灶占比最高,为49.8%(652/1310);患者病灶SUVmax、病变累及范围评分、骨病灶数量及存在软组织肿物的患者例数分别为6.63±3.02、(4.49±3.01)分、10.50(3.00,33.00)个和22例。结论MM患者^18F-FDGPET/CT显像常表现为局限于骨骼系统的轻至中度高代谢溶骨性病变,病灶数量多、范围广、边界清,对于MM的诊断和鉴别诊断有一定价值。Objective To analyze the imaging characteristics of ^18F-fluorodeoxyglucose (FDG) PET/CT in patients with multiple myeloma (MM). Methods Sixty-eight patients (41 males, 27 females, age (61.5±17.2) years) with pathologically proven MM were retrospectively reviewed between January 2011 and August 2016. Imaging characteristics of ^18F-FDG PET/CT in patients were analyzed. Maximum standardized uptake value (SUVmax), score of the bone involvement (bones of whole body were classified into 10 groups, and when 1 group was involved, the score was 1), the number of bone lesions and soft tissue swelling around bone lesions were investigated. Results A total of 1 310 lesions were detected in 68 MM patients. The SUVmax varied widely and mild metabolic activity (2.5≤SUVmax<5.0) was observed in the highest proportion of MM patients (49.8%, 652/1 310). The SUVmax of MM patients was 6.63±3.02. The score of bone involvement was 4.49±3.01. The number of bone lesions was 10.50(3.00, 33.00), and soft tissue swelling around bone lesions was observed in 22 patients. Conclusions There are special imaging characteristics of 18F-FDG PET/CT in MM patients, such as multiple osteolytic lesions with mild to moderate metabolic activity, clear boundary and extensive bone involvement, and lesions usually limit to the skeletal system. The characteristics are of certain value in the diagnosis and differential diagnosis of MM.

关 键 词：多发胜骨髓瘤 正电发射断层显像术 体层摄影术 X线计算机 脱氧葡萄糖 

分 类 号：R730.44[医药卫生—肿瘤] R733.3[医药卫生—临床医学]