青少年焦虑与抑郁的共同遗传基础  

Genetic Basis of Adolescent Anxiety and Depression

作　　者：钞淼 陈杰[1,3] 李子旭 李新影 CHAO Miao;CHEN Jie;LI Zi-xu;LI Xin-ying(CAS Key Laboratory of Mental Health,Institute of Psychology,Beijing 100101,China;Academy of Psychology and Behavior,Tianjin Normal University,Tianjin 300074,China;Department of Psychology,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院心理健康重点实验室,北京100101 [2]天津师范大学心理与行为研究院,天津300074 [3]中国科学院大学心理学系,北京100049

出　　处：《中国临床心理学杂志》2018年第6期1066-1069,共4页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金项目(31530031,31300841,31571154)资助

摘　　要：目的:探讨青少年焦虑与抑郁是否有共同的遗传基础。方法:以北京双生子研究数据库中年龄11-17岁(平均数=14.07,标准差=1.80)的714对同性别双生子为对象,采用自评问卷测量青少年的抑郁和焦虑症状。结果:①双变量遗传分析模型显示,焦虑与抑郁的遗传相关显著,非共享环境相关也显著。②青少年焦虑与抑郁的表型相关由共同的遗传基础解释的比例为63.22%,由共同的非共享环境解释的比例为36.78%。结论:青少年的焦虑与抑郁主要由共同的遗传基础解释。Objective:To investigate whether adolescent anxiety and depression have a common genetic basis.Methods:Participants included 714pairs of same-gender adolescent twins aged 11-17years(M=14.07,SD=1.80)derived from the Beijing Twin Study(BeTwiSt).Self-reported questionnaires were used to measure the depression and anxiety symptoms. Results:①Genedc correlation between depression and anxiety was significant,and non-shared environmental correlation was also significant.②The common genetic factors accounted for 63%of the phenotypic association between adolescent depression and anxiety,while the remainder was explained by common non-shared environments(37%).Conclusion:There is a substantial common genetic basis between adolescent depression and anxiety.

关 键 词：青少年 焦虑 抑郁 双生子 遗传基础 

分 类 号：R395.1[哲学宗教—心理学]