334例垂体瘤患者临床特点及术后随访分析  

Clinical Features and Follow-up of Patients with Pituitary Tumors: An Analysis of 334 Cases

作　　者：罗川东 胡智洪[1] 王英[1] 张捷[1] 杨启荣[1] 樊炜[1] Luo Chuandong;Hu Zhihong;Wang Ying;Zhang Jie;Yang Qirong;Fan Wei(Department of Neurosurgery,People's Hospital in the Central District of Leshan,Leshan 614000,Sichuan,China)

机构地区：[1]乐山市市中区人民医院神经外科,四川乐山614000

出　　处：《肿瘤预防与治疗》2018年第6期402-405,共4页Journal of Cancer Control And Treatment

基　　金：国家自然科学基金(编号:81571131)~~

摘　　要：目的:回顾性分析乐山市市中区人民医院近10年收治的334例垂体瘤患者的临床特点,为提高垂体瘤患者术后生存质量提供相关参考。方法:对2007年1月至2016年12月就诊于我院神经外科的334例临床及随访资料完整的垂体瘤术后患者进行回顾性分析。结果:男女性别比为1. 1∶1,平均年龄(47. 6±12. 8)岁,男性患者的发病年龄略高于女性(48. 9±11. 7 vs 46. 3±11. 4; t=2. 055,P=0. 041)。临床症状以持续性头晕、头痛及恶心、呕吐、抽搐最常见(159例,46. 2%),其次为视力减弱或下降、视物模糊(123例,35. 8%)。大腺瘤检出比例最高(288例,86. 2%)、其次为巨大腺瘤(29例,8. 7%),微腺瘤的检出比例最低(17例,5. 1%)。术前诊断为无功能性瘤31例(9. 3%)、功能性瘤303例(88. 1%),其中以多激素混合瘤最多207例(60. 2%),其次为促甲状腺激素(TSH)瘤57例(16. 6%),而促性激素(LH/FSH)瘤最少2例(0. 6%);术后病理诊断无功能性瘤77例(22. 4%)、功能性瘤257例(74. 7%),其中以泌乳素(PRL)瘤114例(33. 1%)最多,其次为多激素混合瘤74例(21. 5%),而以促甲状腺激素(TSH)瘤最少6例(1. 7%)。手术前后诊断符合率以促肾上腺皮质激素(ACTH)瘤最高(6例,75. 0%),以促性激素(LH/FSH)瘤诊断符合率最低(2例,5. 4%)。结论:垂体瘤多发于30～50岁人群,男性略多于女性,以大腺瘤最为多见,泌乳素(PRL)瘤最为常见,患者多因头晕、头痛,视力减弱或下降、视物模糊等症状就诊,在影像学检查的基础上应更加重视内分泌检查。Objective:To retrospectively analyze the clinical features of 334patients with pituitary tumors treated in the People's Hospital in the Central District of Leshan in recent 10years,which provided references for improving the quality of life in patients with pituitary tumors.Methods:The clinical data of 334patients with pituitary tumors who were treated in the department of neurosurgery from January 2007to December 2016were analyzed retrospectively.Results:The sex ratio of male to female was 1.1:1,the average age was (47.6±12.8)years,and the age of onset of male patients was slightly high- er than that of female patients (48.9±11.7vs 46.3±11.4;t =2.055,P =0.041).The clinical symptoms included persistent dizziness,headache and nausea,vomiting or convulsions (159cases,46.2%),fallowed by decreased vision or bIurred vision (123cases,35.8%).Of all the cases diagnosed before surgery,there were 288cases of adenoma (86.2%),29cases of giant adenoma (8.7%),and 17cases of micro adenoma (5.1%);there were 31cases of non-functioning tumors (9.3%),303cases of functioning tumors (88.1%),of which there were 207cases of plurihormonal adenoma (60.2%),followed by 57cases of thyroid stimulating hormone (TSH)-secreting adenoma (16.6%),and 2cases of gona- dotropm (LI-I/FSH)turdor (0.6%);postoperative pathological diagnosis showed that there were 77cases of non-functioning tumor (22.4%)and 257cases of functioning tumor (74.7%),of which there were 114cases (33.i %)of prolaetinoma (PRL),folIowed by 74cases (21.5%)of phtrihormonal adenoma and 6cases (1.7%)of TSH-secreting adenoma.The di- agnosis of adrenocorticotropic hormone (ACTH)-secreting tumor (6cases,75%)was accurate,and that of LH/FSH tumor (2cases,5.4%)was inaccurate.Conclusion:Pituitary tumors are prone to occur in people of 30~50years old.The inci- dence in men is slightly higher than that in women.The most commonly seen tumors are giant adenoma and PRL.Most pa- tients went to hospital because of dizziness,headache,visual impairment,or loss,blurred vision and other symptoms.We

关 键 词：垂体瘤 临床特点 术后随访 

分 类 号：R739.41[医药卫生—肿瘤]