Hepatoprotective Effects of Folium syringae Extracts Against Ethanolinduced Acute Liver Injury  

作　　者：He Jing-shan Lin Yue-xia Li Chang-wen Li Rui Chang Yi-cong Li Ying Shi Chen-xi Ma Xin Li Zhi Liu Fang-ping 

机构地区：[1]College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China [2]Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development,Harbin 150030,China [3]Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences,Harbin 150069,China

出　　处：《Journal of Northeast Agricultural University(English Edition)》2018年第4期62-70,共9页东北农业大学学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(31472241);the Application Technology Research and Development Projects in Heilongjiang Province of China(PC13S03)

摘　　要：The aim of the study was to investigate the hepatoprotective effects of Folium syringae(FS) extracts against ethanolinduced acute liver injury. Mice and primary hepatocytes were pretreated with FS extracts at different dosages before ethanol administration. Transaminases, glutathione S-transferase A1 level and hepatic biochemical indices(malondialdehyde, superoxide dismutase, glutathione and glutathione peroxidase) were determined. Pretreatment with FS extracts significantly inhibited the damage caused by ethanol and the hepatoprotective effects of FS were almost similar to Silymarin that was used to treat alcoholic liver injury. GSTA1 contents in all the FS extract-treated groups were significantly different from those in the ethanol-induced acute liver injury model group(p<0.01), and similar trends were observed in transaminases and hepatic indices level both in vitro and in vivo. The results showed that FS extracts had hepatoprotective effects against ethanol-induced injury. Those effects might be related to the enhancement of antioxidant capacity of liver cells, and FS extracts could reduce the release of liver GSTA1, which contributed to improve liver detoxification.The aim of the study was to investigate the hepatoprotective effects of Folium syringae(FS) extracts against ethanolinduced acute liver injury. Mice and primary hepatocytes were pretreated with FS extracts at different dosages before ethanol administration. Transaminases, glutathione S-transferase A1 level and hepatic biochemical indices(malondialdehyde, superoxide dismutase, glutathione and glutathione peroxidase) were determined. Pretreatment with FS extracts significantly inhibited the damage caused by ethanol and the hepatoprotective effects of FS were almost similar to Silymarin that was used to treat alcoholic liver injury. GSTA1 contents in all the FS extract-treated groups were significantly different from those in the ethanol-induced acute liver injury model group(p<0.01), and similar trends were observed in transaminases and hepatic indices level both in vitro and in vivo. The results showed that FS extracts had hepatoprotective effects against ethanol-induced injury. Those effects might be related to the enhancement of antioxidant capacity of liver cells, and FS extracts could reduce the release of liver GSTA1, which contributed to improve liver detoxification.

关 键 词：ETHANOL Folium syringae extract GSTA1 liver injury primary hepatocyte MOUSE 

分 类 号：R285.5[医药卫生—中药学]