化疗对晚期胆道系统肿瘤患者TAP及T细胞亚群的影响  

Effect of chemotherapy on TAP and T cell subsets in patients with advanced biliary tract tumors

作　　者：许钰杰 崔瑶[1] 朱琰琰 刘明月[1] XU Yu-jie;CUI Yao;ZHU Yan-yan;LIU Ming-yue(Herman Provincial People's Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院

出　　处：《医药论坛杂志》2018年第11期9-12,共4页Journal of Medical Forum

基　　金：河南省科技攻关计划项目(162102310024)

摘　　要：目的观察晚期胆道系统肿瘤不同化疗疗效组患者TAP及T细胞亚群的变化。方法检测30例晚期胆道系统肿瘤患者化疗前和化疗2周期后不同疗效组外周血TAP及T细胞亚群的变化。结果疗效较佳组(疗效评价为PR+SD,n=17)患者TAP值化疗后较化疗前明显下降,差异具有统计学意义(P<0.05)。化疗后疗效不佳组(疗效评价为PD,n=13)TAP值明显升高,差异具有统计学意义(P<0.05)。疗效不佳组患者化疗前后TAP值均明显高于疗效较佳者,且差异具有统计学意义(P<0.05)。CD4+T淋巴细胞在疗效较佳患者组,化疗后较化疗前升高,差异未具有统计学意义(P>0.05)。在疗效不佳组,化疗后较化疗前降低,差异具有统计学意义(P<0.05)。化疗前后疗效较佳组高于疗效不佳组,差异具有统计学意义(P<0.05)。CD8+T淋巴细胞在疗效较佳患者组,化疗后较化疗前降低,但差异未有统计学意义(P>0.05)。在疗效不佳组,化疗后较化疗前升高,差异具有统计学意义(P<0.05)。化疗前后疗效较佳组低于疗效不佳组,差异具有统计学意义(P<0.05)。CD4+/CD8+T比值在疗效较佳患者组,化疗后较化疗前升高,差异具有统计学意义(P<0.05)。在疗效不佳组,化疗后较化疗前降低,但差异无统计学意义(P>0.05)。化疗前后疗效较佳组高于疗效不佳组,差异具有统计学意义(P<0.05)。结论有效的化疗可以降低晚期胆道系统肿瘤患者血清中与肿瘤转移复发相关的TAP水平,升高CD4+/CD8+、CD4+T淋巴水平,降低晚期胆道系统肿瘤患者的转移复发风险,改善晚期胆道系统肿瘤患者的细胞免疫功能并提高机体的免疫力。Objective To observe the changes of TAP( Tumor abnormal protein) and t-cell subsets in patients with advanced biliary tract tumors( intrahepatic cholangiocarcinoma,extrahepatic cholangiocarcinoma and cholecystic carcinoma) in different therapeutic groups of chemotherapy. Methods Changes of TAP and t-cell subsets in peripheral blood of 30 patients with advanced biliary tract tumors before and after 2 cycles of chemotherapy were detected. Results The TAP value of the patients in the group with better efficacy( the efficacy was evaluated as PR and SD,n = 17) decreased significantly after chemotherapy than before,and the difference was statistically significant( P < 0. 05). TAP value was significantly increased in the group with poor efficacy( the efficacy was evaluated as PD,n = 13) after chemotherapy,and the difference was statistically significant( P < 0. 05). The TAP values of patients with poor curative effect before and after chemotherapy were significantly higher than those with better curative effect,and the difference was statistically significant( P < 0. 05). CD4^+T lymphocytes increased after chemotherapy in patients with better efficacy,and the difference not statistically significant( P > 0. 05). In the group with poor curative effect,the rate was lower after chemotherapy than before,but the difference was statistically significant( P < 0. 05). The group with good curative effect before and after chemotherapy was higher than the group with poor curative effect. The difference was statistically significant( P < 0. 05). CD8^+T lymphocytes were decreased after chemotherapy in the group with better efficacy,but the difference was not statistically significant( P > 0. 05). It increased after chemotherapy in the group with poor efficacy,and the difference was statistically significant( P < 0. 05).The group with better curative effect before chemotherapy was lower than the group with poor curative effect. The difference was statistically significant( P < 0. 05). The group with better efficacy after chemotherapy

关 键 词：化疗 晚期胆道系统肿瘤 肿瘤异常蛋白 T细胞亚群 

分 类 号：R73[医药卫生—肿瘤]