清热利湿汤治疗脾胃湿热型口腔扁平苔藓临床研究  

Clinical Study on Qingre Lishi Tang for Oral Lichen Planus of Dampness-heat of Spleen and Stomach Type

作　　者：林昌[1] LIN Chang

机构地区：[1]湖州市中心医院口腔科,浙江湖州313000

出　　处：《新中医》2018年第12期172-174,共3页New Chinese Medicine

摘　　要：目的:观察清热利湿汤治疗脾胃湿热型口腔扁平苔藓(OLP)的临床效果。方法:将60例脾胃湿热型OLP患者随机分为对照组和观察组各30例。对照组给予转移因子口服液治疗,观察组给予清热利湿汤治疗。治疗后评估2组临床疗效,观察2组治疗前后相关指标的变化情况。结果:观察组治疗总有效率90.00%,高于对照组的66.67%,差异有统计学意义(P <0.05)。治疗前,2组症状、体征积分比较,差异均无统计学意义(P> 0.05)。治疗后,2组症状、体征积分均较治疗前降低,差异均有统计学意义(P <0.05);观察组症状、体征积分均低于对照组,差异均有统计学意义(P <0.05)。治疗前,2组IgA、IgG水平比较,差异均无统计学意义(P> 0.05)。治疗后,2组IgA水平与治疗前比较,差异均无统计学意义(P> 0.05);2组IgG水平均较治疗前降低,差异均有统计学意义(P <0.05);观察组IgG水平低于对照组,差异有统计学意义(P <0.05)。结论:清热利湿汤治疗脾胃湿热型OLP,可有效改善患者的临床症状及免疫指标。Objective:To observe the clinical effect of Qingre Lishi tang for oral lichen planus(OLP) of dampness-heat of spleen and stomach type. Methods:Divided 60 cases of patients with OLP of dampness-heat of spleen and stomach type into the control group and the observation group randomly, 30 cases in each group. The control group received transfer factor oral solution for treatment, while the observation group received Qingre Lishi tang. After treatment, evaluated the clinical effect and observed the changes in relevant indexes before and after treatment in the two groups. Results:The total effective rate was 90.00% in the observation group, higher than that of 66.67% in the control group,the difference being significant (P<0.05). Before treatment,no significant difference was found in the comparisons of the scores of symptoms and signs between the two groups(P>0.05). After treatment,the scores of symptoms and signs in the two groups were decreased when compared with those before treatment,differences being significant(P < 0.05). The scores of symptoms and signs in the observation group were lower than those in the control group, the difference being significant(P<0.05). Before treatment,no significant difference was found in the comparisons of the levels of IgA and IgG between the two groups(P>0.05). After treatment,compared with the levels of IgA in the two groups before treatment,there was no significance in the difference (P>0.05). Levels of IgG in the two groups were decreased when compared with those before treatment,differences being significant (P<0.05). Level of IgG in the observation group was lower than that in the control group, the difference being significant(P<0.05). Conclusion:Qingre Lishi tang for OLP of dampness-heat of spleen and stomach type can effectively improve the clinical symptoms and immune indexes of patients.

关 键 词：口腔扁平苔藓(OLP) 脾胃湿热 清热利湿汤 转移因子口服液 疗效 免疫指标 

分 类 号：R781.5[医药卫生—口腔医学]