抗-SLA/LP在自身免疫性肝炎的诊断、分型及病情评估中的应用价值  

The Clinical Value of SLA/LP for the Diagnosis, Classification and Disease Assessment of Autoimmune Hepatitis

作　　者：邓飞[1] 郭志娟 祝国华[1] 李文清[1] 姚佳佳[1] DENG Fei;GUO Zhi-juan;ZHU Guo-hua;LI Wen-qing;YAO Jia-jia(Department of Laboratory Medicine,Qinghai Hospital of T.CM,Xining,Qinghai,810000,China;Department ofpathology The Affiliated Hospital of Inner Mongolia Medical University,Huhhot,Inner Mongolia,010010,China)

机构地区：[1]青海省中医院检验科,青海西宁810000 [2]内蒙古医科大学附属人民医院病理科,内蒙古呼和浩特010010

出　　处：《现代生物医学进展》2018年第22期4353-4356,共4页Progress in Modern Biomedicine

基　　金：卫生部直属吴阶平医学基金会临床科研专项资助基金项目(320.6750.17357);青海省科技计划基金项目(2017-ZJ-713)

摘　　要：目的:探讨抗-SLA/LP在自身免疫性肝炎的诊断、分型及病情评估中的应用价值。方法:选择2014年1月～2018年1月在我院诊治的自身免疫性肝炎患者82例进行回顾性分析,所有患者经组织学检查、临床症状及生化指标等综合诊断为自身免疫性肝炎,抗-SLA/LP阳性16例、抗-SLA/LP阴性66例,AIH-Ⅰ型51例、AIH-Ⅱ型15例、AIH-Ⅲ型16例。分析和比较抗-SLA/LP阴性和阳性患者的一般临床资料,抗-SLA/LP诊断AIH-Ⅲ型的灵敏度,比较抗-SLA/LP不同强度患者的临床和免疫功能相关指标。结果:抗-SLA/LP阴性和阳性患者的年龄、病程、ANA和AMA检出率无显著性差异,但抗-SLA/LP阳性患者的SMA检出率为0.00%,与抗-SLA/LP阴性患者相比具有统计学差异(P<0.05);抗-SLA/LP诊断AIH-Ⅲ型的灵敏度为100%,准确度为100%;抗-SLA/LP中高强度组患者的PTA和β2-微球蛋白水平均显著高于低强度阳性组(P<0.05),两组患者的免疫指标比较均无显著性差异(P>0.05)。结论:抗-SLA/LP对AIH-Ⅲ型患者的诊断具有高度的灵敏度和准确性,且抗-SLA/LP阳性强度可在一定程度上反映患者肝脏功能,对患者病情的评估具有一定的意义。Objective: To explore the clinical value of anti-SLA/LP for the diagnosis, classification and evaluation of autoimmune hepatitis (AIH). Methods: 82 patients with AIH admitted in our hospital from January 2014 to January 2014 were retrospectively analyzed. All THE patients were diagnosed by histological examination, clinical symptoms and biochemical indexes. Anti-SLA/LP(+) were found in 16 cases, anti-SLA/LP(-) were found in 66 cases. Among them, there were 51 cases of AIH-Ⅰ, 15 cases of AIH-Ⅱ and 16 cases of AIH-Ⅲ. The clinical data of patients with negative and positive anti-SLA/LP, the sensitivity and accuracy of anti-SLA/LP for the diagnosis of AIH- Ⅲ , the clinical and related parameters of immune function in patients with different degree of anti-SLA/LP were analyzed. Results: There was no significant difference in the age, course, ANA and AMA detection rate between two groups. The detection rate of SMA was 0.00% in anti-SLA/LP positive patients, there were statistical differences compared with the anti-SLA/LP negative patients (P<0.05). The sensitivity and accuracy of anti-SLA/LP for the diagnosis of AIH-Ⅲ were 100% respectively. Both PTA and β2-microglobulin levels in the high-intensity positive group were significantly higher than those in the low-intensity positive group (P<0.05), and there was no significant difference between the other clinical indicators and immune indicators between high-intensity and low-intensity positive patients (P<0.05). Conclusions: Anti-SLA/LP had high sensitivity and accuracy for the diagnosis of patients with AIH-Ⅲ, and the SLA/LP positive intensity can reflect the liver function and had certain significance for the assessment of the disease condition.

关 键 词：抗-SLA/LP 自身免疫性肝炎 诊断 分型 病情评估 

分 类 号：R575.1[医药卫生—消化系统]