四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效评价及对血清ox-LDL、CRP、IL-6的影响  

Efficacy of Siqi Decoction and Paroxetine in Treatment of Post-Stroke Depression and Serum ox-LDL, CRP and IL-6 Levels

作　　者：李毓新[1] 刘利宁[1] 吉智[1] 周琪[1] 范秀博 LI Yu-xin;LIU Li-ning;JI Zhi;ZHOU Qi;FAN Xiu-bo(The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi,710038, China)

机构地区：[1]西安医学院第二附属医院,陕西西安710038

出　　处：《现代生物医学进展》2018年第21期4148-4151,共4页Progress in Modern Biomedicine

基　　金：陕西省科技计划项目(2009K01-80)

摘　　要：目的:探讨四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效及对血清氧化低密度脂蛋白(ox-LDL)、C反应蛋白(CRP)、白细胞介素-6(IL-6)的影响。方法:选择我院2014年9月～2016年9月收治的86例脑卒中后抑郁患者,按治疗方式分为对照组与实验组,每组43例。对照组予以帕罗西汀治疗,实验组在对照组基础上加用四七汤治疗,两组均持续治疗8周。比较两组的临床疗效,治疗前后中医症候积分、血清ox-LDL、CRP、IL-6、汉密顿抑郁量表(HAMD)、纳维亚神经卒中量表评分(SNSS)的变化及不良反应的发生情况。结果:治疗后,实验组治疗总有效率显著高于对照组(P<0.05);两组中医症候积分、血清ox-LDL、CRP、IL-6、HAMD、SNSS评分均显著下降,且实验组以上指标均明显低于对照组,差异有统计学意义(P<0.05)。两组不良反应的发生率比较差异无统计学意义(P>0.05)。结论:四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效优于单用帕罗西汀者,能够有效改善患者的临床症状,可能与其更有效降低患者血清ox-LDL、CRP、IL-6水平有关。Objective: To investigate the efficacy of Siqi decoction and paroxetine in the treatment of patients with post-stroke depression and effect on the serum oxidized low density lipoprotein (ox-LDL), C-reactive protein (CRP) and interleukin-6 (IL-6) levels. Methods: 86 cases of patients with post-stroke depression in our hospital from September 2014 to September 2016 were divided into the control group and the experimental group, with 43 cases in each group. The control group was treated by paroxetine treatment, while the experimental group was treated with Siqi decoction based on the control group, both groups were treated for eight weeks. The curative effect, changes of chinese medicine symptom integral, serum ox-LDL, CRP, IL-6 levels, Hamilton depression scale (HAMD) and the scandinavians nerve stroke scale score (SNSS) levels and incidence of adverse reactions were compared between two group. Results: After treatment, the total effective rate of experimental group was significantly higher than that of the control group (P<0.05). The Chinese traditional Chinese medicine, serum ox-LDL, CRP, IL-6, HAMD, SNSS scores of both group were significantly lower than those before treatment, which were significantly lower in the experimental group than those of the control group (P<0.05). No statistically significant difference was found in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The curative effect of Siqi decoction and paroxetine was better than that that paroxetine alone in treatment patients with poststroke depression, it can effectively improve the clinical symptoms, which may be related to the reduce of serum levels of ox-LDL, CRP and IL-6.

关 键 词：脑卒中后抑郁 四七汤 帕罗西汀 疗效 氧化低密度脂蛋白 C反应蛋白 白细胞介素-6 

分 类 号：R743[医药卫生—神经病学与精神病学]