米那普仑对老年抑郁症的疗效分析  

Analysis of the Curative Effect of Minapuram on Senile Depression

作　　者：韩亚琼[1] 涂荣蓉 陈永新[1] 汤光花 HAN Ya-qiong;TU Rong-rong;CHEN Yong-xin;TANG Guang-hua(Department of Pharmacy,Second Affiliated Hospital,Xinxiang,Henan 453002;Emergency Department,Henan Rongjun Hospital,Xinxiang,Henan 453002)

机构地区：[1]新乡医学院第二附属医院药学部,河南新乡453002 [2]河南省荣军医院急诊科,河南新乡453002

出　　处：《智慧健康》2018年第33期58-59,共2页Smart Healthcare

摘　　要：目的探讨米那普仑对老年抑郁症的临床治疗效果。方法选择院内收治的66例老年抑郁症患者,随机将其分为对照组和观察组各33例,对照组给予艾司西酞普兰进行治疗,观察组给予米那普仑进行治疗,对比两组临床疗效。结果两组HAMD和HAMA量表评分治疗后均显著低于治疗前,比较差异有统计学意义(P<0.05);两组临床有效率比较差异无统计学意义(P>0.05);观察组不良反应发生率30.3%显著低于对照组的45.5%,两组比较差异有统计学意义(P<0.05)。结论对于老年抑郁症患者而言,两种药物均有较佳的临床治疗效果,患者依从性均较好,但相较而言,米那普仑临床应用更安全,故值得临床推广应用。Objective To investigate the clinical effect of milnacipran on elderly depression.Methods Sixtysix elderly patients with depression were enrolled in the hospital.They were randomly divided into control group and observation group,33 cases.The control group was treated with escitalopram.The observation group was given milnacipran for treatment,and the clinical efficacy of the two groups was compared.Results The scores of HAMD and HAMA scales in the two groups were significantly lower than those before treatment,and the difference was statistically significant (P<0.05).There was no significant difference in clinical effective rate between the two groups (P>0.05).The incidence of reaction was 30.3%,which was significantly lower than that of the control group 45.5%. The difference between the two groups was statistically significant (P<0.05).Conclusion For elderly patients with depression,both drugs have better clinical treatment effect,and patient compliance is better,but compared with milnacipran,clinical application is safer,so it is worthy of clinical application.

关 键 词：抑郁症 老年人 米那普仑 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]