APE1基因rs1760944多态性与前列腺癌易感性的Meta分析  

Associations between APE1 rs1760944 polymorphism and susceptibility to prostate cancer

作　　者：惠鹏宇[1] 倪锋[1] 熊虎[2] 杜永辉[1] 胡小剑[1] HUI Peng-yu;NI Feng;XIONG Hu;DU Yong-hui;HU Xiao-jian(Department of Urology,Second Affiliated Hospital of Xi'an Medical University,Xi'an 710038,China;Department of Obstetrics and Gynecology Reproductive Medicine Center,Fourth Military Medical University Tangdu Hospital,Xi'an 710038,China)

机构地区：[1]陕西省西安医学院第二附属医院泌尿外科,西安710038 [2]第四军医大学唐都医院妇产科生殖医学中心,西安710038

出　　处：《中国肿瘤临床与康复》2018年第12期1443-1447,共5页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：西安医学院第二附属医院院级课题(16KY0105)

摘　　要：目的通过Meta分析评估人群中APE1基因rs1760944多态性与前列腺癌风险之间的关系。方法电子检索中国维普(VIP)、中国知网(CNKI)、万方数据库、Pub Med及Web of Science数据库中符合条件的病例-对照研究。检索时间为建库以来至2016年6月1号。通过Stata 12. 0软件计算比值比(OR)和95%可信区间(95%CI),从而评估APE1基因rs1760944多态性与前列腺癌易感性的相关性。结果本研究纳入6篇文献,共9项有关APE1基因rs1760944多态性和前列腺癌风险相关的研究,包含5 236例前列腺癌患者和4 610例健康对照。结果发现,在五种基因模型下,APE1基因rs1760944多态性与前列腺癌易感性间存在显著相关性,差异均有统计学意义(均P <0. 05)。此外,以种族类型为依据的亚组分析中,发现亚洲人种和高加索人种分别与前列腺癌易感性相关,差异均有统计学意义(均P <0. 05)。结论 APE1基因rs1760944多态性是前列腺癌易感性的一个危险因素。Objective To evaluate the relationship between apurinic/apyrimidinic endonuclease 1( APE1) rs1760944 polymorphism and prostate cancer( PCa) risk. Methods We searched Database for Chinese Technical Periodicals( VIP),Chinese National Knowledge Infrastructure( CNKI),Wanfang databases,Pub Med and Web of Science for the eligible case-control studies up to June 1,2016. Stata 12. 0 was used to calculate odds ratios( ORs) and 95% confidence intervals( 95% CIs) to estimate the associations between APE1 polymorphism and susceptibility to prostate cancer. Results A total of 6 literatures were inclused in the current study. Nine was on APE1 rs1760944 polymorphism and prostate cancer risk,including5236 patients with prostate cancer and 4610 healthy controls. Overall,APE1 rs1760944 polymorphism was significantly associated with the risk of PCa in five genetic models( all P<0. 05). In addition,in the ethnicity-specific analysis,we also uncovered a significant association between Asian and Caucasoid population and prostate cancer( all P<0. 05). Conclusion Our findings support that APE1 rs1760944 polymorphism is a risk factor for prostate cancer.

关 键 词：APE1 多态性 前列腺肿瘤 META分析 

分 类 号：R737.25[医药卫生—肿瘤]