明胶海绵微粒-TACE治疗15例大肝癌术后外周血Treg细胞的变化及意义  

Postoperative changes and its significance of Treg cells in peripheral blood after GSMs-TACE treatment for large hepatocellular carcinoma in 15 patients

作　　者：任志忠 刘影 岳元勋 杨晓伟 黄鑫[1] 张跃伟 REN Zhizhong;LIU Ying;YUE Yuanxun;YANG Xiaowei;HUANG Xin;ZHANG Yuewei(Department of Hepatobiliary Intervention, Affiliated Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China)

机构地区：[1]清华大学附属北京清华长庚医院肝胆介入科、清华大学临床学院,102218

出　　处：《介入放射学杂志》2018年第12期1151-1154,共4页Journal of Interventional Radiology

基　　金：国家自然科学基金(81571783).

摘　　要：目的初步探讨应用明胶海绵微粒(GSMs)行TACE治疗大肝癌术后外周血中调节性T淋巴细胞(Treg)变化及意义。方法应用流式细胞技术检测健康组和大肝癌患者GSMs-TACE术前与术后第10天、第22天外周血Treg细胞的含量。结果选择健康人7名,符合入组标准的肝癌患者共计15例。外周血中Treg细胞含量:健康对照组为(8.64±1.94)%;肝癌患者术前为(11.52±3.78)%,术后第10天为(9.07±1.94)%,与术前相比显著下降(P=0.039),术后第22天为(9.96±1.48)%,与术前比较差异有统计学意义(P=0.028)。结论 GSMs-TACE治疗大肝癌能够显著降低外周血Treg细胞的含量,表明该方法对机体免疫功能有正向调节作用。Objective To study on the postoperative changes and its significance of regulatory T lymphocytes(Treg cells) in peripheral blood after transcatheter arterial chemoembolization with gelatin sponge microparticles(GSMs-TACE) for large hepatocellular carcinoma(HCC). Methods By using flow cytometry,the contents of Treg cells in peripheral blood were determined before and 10 days, 22 days after GSMs-TACE in both health control group and patients with large HCC(study group). Results Seven healthy subjects and15 HCC patients, whose clinical data met the inclusion criteria, were enrolled in this study. The content of Treg cells in peripheral blood in healthy control group was(8.64 ±1.94)%. The content of Treg cells in peripheral blood in HCC patients before GSMs-TACE was(11.52±3.78)%, which was decreased to(9.07±1.94)% at 10 days and to(9.96±1.48)% at 22 days after GSMs-TACE respectively, the postoperative values in Treg cells content were statistically significantly different from the preoperative one(P=0.039 and P=0.028 respectively). Conclusion For the treatment of large HCC, GSMs-TACE can significantly reduce the content of Treg cells in peripheral blood, indicating that this method has a positive regulatory effect on the immune function of human body.

关 键 词：肝细胞肝癌 肝动脉化疗栓塞术 调节性T淋巴细胞 明胶海绵微粒 

分 类 号：R735.7[医药卫生—肿瘤]