微粒-TACE同步治疗肝癌伴Ⅲ型门静脉癌栓6例  

GSMs-TACE simultaneous therapy for hepatocellular carcinoma with type Ⅲ portal vein tumor thrombus: initial results in 6 patients

作　　者：张跃伟 刘影 任志忠 岳元勋 韩东冬[2] ZHANG Yuewei;LIU Ying;REN Zhizhong;YUE Yuanxun;HAN Dongdong(Department of Hepatobiliary Intervention, Affiliated Beijing Tsinghua Changgung Hospital,School of Clinical Medicine, Tsinghua University, Beijing 102218, China)

机构地区：[1]清华大学附属北京清华长庚医院(清华大学临床医学院)肝胆介入科,北京102218 [2]清华大学附属北京清华长庚医院(清华大学临床医学院)肝胆胰外科,北京102218

出　　处：《介入放射学杂志》2018年第12期1186-1189,共4页Journal of Interventional Radiology

基　　金：国家自然科学基金(81571783)

摘　　要：目的探讨应用明胶海绵微粒经肝动脉化疗栓塞(GSMs-TACE)同步治疗肝癌伴Ⅲ型门静脉癌栓患者的安全性及临床疗效。方法应用GSMs-TACE治疗6例Ⅲ型伴门静脉癌栓肝癌患者。患者Child-Pugh分级均为A级。术后结合影像学改变、AFP下降情况、肝功损伤情况、生存时间及术后不良反应综合评估安全性及临床疗效。结果 6例患者共行介入22(2～5)次GSM-TACE,中位介入次数为4次;中位随访时间16.5(9～33)个月,6个月后6例患者均生存,术后均无急性肝衰竭、上消化道出血等严重并发症发生。结论应用GSMs-TACE同步治疗Child-Pugh分级A级的肝癌伴Ⅲ型门静脉癌栓患者,具备良好的安全性及临床疗效。Objective To discuss the efficacy and safety of transarterial chemoembolization(TACE)plus gelatin sponge microparticles(GSMs) simultaneous therapy in treating patients with hepatocellular carcinoma(HCC) complicated by type Ⅲ portal vein tumor thrombosis(PVTT). Methods Six patients with HCC complicated by type Ⅲ PVTT underwent GSMs-TACE treatment. The Child-Pugh was grade A in all patients. After GSMs-TACE treatment, the safety and clinical efficacy of GSMs-TACE were comprehensively evaluated by the imaging findings, the decrease in alpha-fetoprotein(AFP) level, the injury of liver function,the survival time and the postoperative adverse reactions. Results A total of 22 times of GSMs-TACE procedure were carried out in the 6 patients(2-5 times per patient), the median interventions was 4 times.The median follow-up period was 16.5 months(9-33 months). The overall 6-month survival rate was 100%.No severe complications such as acute hepatic failure, upper gastrointestinal bleeding, etc. occurred in all 6 patients. Conclusion In treating patients with HCC of Child-Pugh grade A which is complicated by type ⅢPVTT, TACE plus GSMs simultaneous therapy has reliable safety and clinical effect.

关 键 词：肝癌 门静脉癌栓 明胶海绵微粒 化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤]