青龙衣抗肿瘤有效成分的药理活性及其作用机制研究进展  

Research progress of pharmacological activity and action mechanism of active anti-tumor ingredients of Qinglongyi

作　　者：刘雪澜 黄丹 段玉敏 LIU Xue-Lan;HUANG Dan;DUAN Yu-Min(College of Chemistry and Engineering,Shenyang Normal University,Shenyang 110034,China;College of Grain Science and Technology Shenyang Normal University,Shenyang 110034,China;College of Preschool and Primary Education Shenyang Normal University,Shenyang 110034,China)

机构地区：[1]沈阳师范大学化学化工学院,沈阳110034 [2]沈阳师范大学粮食学院,沈阳110034 [3]沈阳师范大学学前与初等教育学院,沈阳110034

出　　处：《食品安全质量检测学报》2018年第24期6443-6448,共6页Journal of Food Safety and Quality

基　　金：辽宁省科学技术计划面上项目(2015020551)~~

摘　　要：青龙衣是我国重要的抗肿瘤药源植物,且随着研究的深入,其药用价值也越来越显著。青龙衣不仅具有良好的抗肿瘤作用,还具有一定的市场开収价值。本文查阅近年来国内外相兲文献,总结归纳了青龙衣抗肿瘤有效成分的药理活性和作用机制。青龙衣抗肿瘤有效成分的药理活性分为醌类、多糖类、多酚类、黄酮类、萜类、二芳基烷庚类等。青龙衣的抗肿瘤作用机制可大致分为抑制细胞生长、影响细胞周期、影响线粒体变化、抑制基因表达、抑制肿瘤细胞侵袭转移等。通过研究,以期为抗肿瘤新药的研収提供依据。Qinglongyi is an important anti-tumor drug source plant in China, and its medicinal value has become more and more obvious with the deepening of research. Qinglongyi has good anti-tumor effect, and has certain market development value. This paper reviewed the related literatures at home and abroad for recent years, and summarized the pharmacological activity and mechanism of active anti-tumor components of Qinglongyi. The pharmacological activities of the active anti-tumor components of Qinglongyi can be divided into terpenoids, polysaccharides, polyphenols, flavonoids, anthraquinones, diarylheptanoids, etc. The anti-tumor mechanism of Qinglongyi can be roughly divided into inhibiting cell growth, affecting cell cycle, affecting mitochondrial changes, inhibiting gene expression, inhibiting invasion and metastasis of tumor cells. Through the research, it aims to provide the basis for the research and development of new anti-tumor drugs.

关 键 词：青龙衣 抗肿瘤 药理活性 作用机制 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]