胆囊结石病人胆囊组织Cajal间质细胞数目变化及其收缩功能的相关性研究  

Study on the number of Cajal interstitial cells in gallbladder tissue and its correlation with contractile function in patients with cholecystolithiasis

作　　者：台剑熊 许丙辉[1] 李恒力[1] 齐双玉[1] TAI Jianxiong;XU Binghui;LI Hengli(Department of Hepatobiliary Surgery,Harrison International Heping Hospital,Hengshui City,Hebei Province,Hengshui 053000,China)

机构地区：[1]哈励逊国际和平医院肝胆外科,河北衡水053000

出　　处：《临床外科杂志》2018年第11期865-867,共3页Journal of Clinical Surgery

摘　　要：目的探讨胆囊结石病人胆囊组织Cajal间质细胞(ICC)数目变化及与其收缩功能相关性。方法胆囊切除术病人103例,根据是否存在胆囊结石分为胆结石组和非胆结石组,分别有54例和49例。空腹饮酸奶后采用B超检查检测胆囊收缩功能,并计算45分钟胆囊收缩率。术中切除胆囊组织作为标本,分别切除颈、体、底各部位组织做切片,长度分别为0. 2 cm、0. 5 cm及0. 8 cm,采用免疫荧光法测定ICC数目。结果胆结石组病人的胆囊收缩率和ICC数目均明显低于非胆结石组(P <0. 05)。Person相关分析显示,胆囊收缩率与胆囊组织ICC数目呈正相关(r=0. 137,P> 0. 05)。结论胆囊结石病人胆囊组织中ICC数目明显降低,同时伴随着胆囊收缩功能下降,但两者并非存在单纯线性关系,可能存在其他对影响胆囊收缩功能的因素。Objective To study the Cajal interstitial cells of gallbladder tissue in patients with cholecystolithiasis.Methods The subjects were 103 patients with indirect cholecystectomy were divided into gallstone group(54 cases)and non-gallstone group(49 cases)according to the existence of gallstone. The gallbladder contraction rate was calculated at 45 Min.The gallbladder tissue was excised as a specimen during the operation,and the neck,body and bottom tissues were sectioned respectively,the length was 0.2 cm,0.5 cm,0.8 cm,respectively.The number of ICC was determined by immunofluorescence method. Results The rate of gallbladder contraction and the number of ICC in gallstone group were significantly lower than those in non-cholelithiasis group (P <0.05).The rate of gallbladder contraction was positively correlated with the number of ICC in gallbladder tissue(r =0.137,P >0.05).Conclusion The number of ICC in gallbladder tissue of patients with gallstone was significantly decreased and the contraction function of gallbladder was decreased.However,there is not a simple linear relationship between the two factors,and there are other reasons for the effect of gallbladder contraction function,which can be used as a new direction in the treatment of cholecystolithiasis.

关 键 词：胆囊结石 CAJAL间质细胞 收缩功能 相关性 

分 类 号：R575.6[医药卫生—消化系统]