关注血管钙化的起源、演进与转归研究  

Focus on the origin,evolution and prognosis of vascular calcification

作　　者：王中群(主持)[1] 李丽华[2] WANG Zhongqun;LI Lihua(Department of Cardiology,Affiliated Hospital of Jiangsu University,Zhengjiang,Jiangsu 212001,China;Department of Pathology,Affiliated Hospital of Jiangsu University,Zhengjiang,Jiangsu 212001,China)

机构地区：[1]江苏大学附属医院心内科,江苏省镇江市212001 [2]江苏大学附属医院病理科,江苏省镇江市212001

出　　处：《中国动脉硬化杂志》2018年第11期1086-1090,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(81770450、81370408);江苏省“六大人才高峰”项目(WSN-044);江苏省青年医学人才项目(QNRC2016836);镇江市心血管病临床医学研究中心项目(SS2018008)

摘　　要：血管钙化是动脉壁间叶细胞尤其是平滑肌细胞在各种病理因素作用下转分化为成骨成软骨细胞表型,介导钙盐异常沉积在血管壁的过程,包括内膜钙化、中膜钙化及瓣膜钙化等多种病理类型。随着我国老龄化趋势的不断加剧,尤其是糖尿病、动脉粥样硬化及慢性肾脏病等的患病率持续走高,由其衍生的血管钙化正在逐渐演变为影响我国人民健康的一个关键疾病谱。为此,本文从血管钙化的起源、演进及转归,尤其是转归过程中的骨与血管、主动与被动、内膜钙化与中膜钙化、微钙化与大钙化以及自噬、内质网应激和非编码RNA等争议和热点问题入手,进行了系统阐述,希冀通过本文和专栏内多位专家以及一直奋战在钙化领域内广大同道的共同努力,一起推动血管钙化基础与临床研究的前行。Vascular calcification is a process of arterial wall mesenchymal cells, especially smooth muscle cells, transforming into the phenotype of chondroblast and osteoblast under the effect of various pathological factors.It mediates the process of abnormal calcium deposition in the vascular wall.Vascular calcification includes various pathological types such as intimal calcification, medial calcification, and valve calcification.With the increase of aging population, especially the prevalence rate of diabetes, atherosclerosis as well as chronic kidney disease continues to rise, the vascular calcification derived from which is gradually becoming a key disease spectrum affecting the health of our people.For that reason, the thesis starts from the origin, evolution and prognosis of vascular calcification, systematically discusses some controversial and hotspot issues in the process of prognosis such as bone and blood vessel, active and passive, intimal and medial calcification, microcalcification and macrocalcification, autophagy, endoplasmic reticulum stress and non-coding RNA.It hopes to promote the advancement of basic and clinical research on vascular calcification through the joint efforts of experts who devote in the calcification.

关 键 词：血管钙化 起源 演进 转归 

分 类 号：R363[医药卫生—病理学]