lncRNA在钙化性主动脉瓣疾病中的作用研究新进展  

Recent advances of lncRNAs in calcific aortic valve disease

作　　者：陈子英 王思颖 朱东兴 CHEN Ziying;WANG Siying;ZHU Dongxing(Biomedical Research Center,Basic Medical School,Guangzhou Medical University,Guangzhou,Guangdong 511436,China)

机构地区：[1]广州医科大学基础学院基础医学研究中心

出　　处：《中国动脉硬化杂志》2018年第11期1116-1118,1146,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金青年基金项目(81800428);广东省教育厅特色创新项目(2017KTSCX158);广东省科技创新战略专项资金项目(2018A030310178)

摘　　要：钙化性主动脉瓣疾病是老年人群中最常见的一种心脏瓣膜疾病,目前尚无有效药物逆转或预防其发病过程。钙化性主动脉瓣疾病致病过程高度类似于骨代谢和骨发育,但其具体致病机制尚不完全清楚。lncRNA是一种长度大于200个核苷酸的非编码RNA,具有重要的生物学功能。诸多研究表明lncRNA在钙化性主动脉瓣疾病中有表达差异,并通过不同机制参与钙化性主动脉疾病的发生。本文将综述近年来lncRNA与钙化性主动脉瓣疾病的重要进展,为进一步理解钙化性主动脉瓣疾病发生发展的分子机制提供依据。Calcific aortic valve disease is frequently observed in the elderly.Currently, there is no treatment to reverse established calcific aortic valve disease.The responsible underlying molecular mechanisms have yet to be fully elucidated.Previous studies have demonstrated that calcific aortic valve disease shares many similarities to that of bone formation and bone metabolisms.lncRNAs are defined as non-coding transcripts longer than 200 nucleotides, with important biological functions.Emerging data have shown that lncRNAs differentially express in calcified aortic valves compared to normal control, which contribute significantly to the pathogenesis of calcific aortic valve disease through a number of distinct mechanisms.This study reviews here the current progress of lncRNAs and calcific aortic valve disease in recent years.These studies shed new lights on pathogenic mechanisms of calcific aortic valve disease.

关 键 词：lncRNA 瓣膜间质细胞 成骨样细胞转分化 钙化性主动脉瓣疾病 

分 类 号：R363[医药卫生—病理学]