清道夫受体BI与动脉粥样硬化  

Scavenger receptor BI and atherosclerosis

作　　者：杜芬[1] 喻红[1] DU Fen;YU Hong(School of Basic Medical Sciences,Wuhan University & Hubei Key Laboratory of Developmental Diseases,Wuhan,Hubei 430071,China)

机构地区：[1]武汉大学基础医学院湖北省发育源性疾病重点实验室

出　　处：《中国动脉硬化杂志》2018年第11期1177-1183,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81670423、81670412、81270364)

摘　　要：清道夫受体B族I型(SR-BI)是细胞膜上首个被定义为高密度脂蛋白(HDL)受体的糖蛋白,其介导细胞选择性摄取高密度脂蛋白胆固醇(HDLC),影响细胞胆固醇平衡、炎症表型。肝脏SR-BI在胆固醇逆向转运中扮演重要角色,而与HDL的代谢及其抗动脉粥样硬化(As)作用密切相关,并且已发现人类存在SR-BI基因多态性。本文重点从SR-BI结构、功能、调节及其对As的作用进行综述。Scavenger receptor type B class I (SR-BI) is the first glycoprotein defined as a high density lipoprotein (HDL) receptor on the cell membrane, which mediates the selective uptake of high density lipoprotein cholesterol (HDL) by cells, affecting cell cholesterol balance and inflammatory status.Liver SR-BI plays an important role in reverse cholesterol transport, and is closely related to HDL metabolism and its role in anti-atherogenesis.It has been found that humans have SR-BI gene polymorphisms.This review focuses on SR-BI structure, function, regulation and its role on atherosclerosis.

关 键 词：清道夫受体BI 高密度脂蛋白 胆固醇代谢 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]