防治血管钙化,依然任重道远  

Prevention and treatment of vascular calcification,still a long way to go

作　　者：王中群 孙振[2] WANG Zhongqun;SUN Zhen(Jiangsa Institute of Nuclear Medicine,Wuxi,Jiangsu 214063,China;Department of Cardiology,Affiliated Hospital of Jiangsu University,Zhenjiang ,Jiangsu 212001,China)

机构地区：[1]江苏省原子医学研究所,江苏省无锡市214063 [2]江苏大学附属医院心内科,江苏省镇江市212001 [3]镇江市心血管病临床医学研究中心 [4]中国动脉粥样硬化专业委员会胆固醇逆向转运专家组 [5]中国药理学会表观遗传药理学专业委员会 [6]中国中药协会心血管药物研究专业委员会

出　　处：《中国动脉硬化杂志》2018年第12期1189-1193,共5页Chinese Journal of Arteriosclerosis

基　　金：卫生部核医学重点实验室、江苏省分子核医学重点实验室开放课题项目(KF201504);国家自然科学基金项目(81770450、81370408);江苏省“六大人才高峰”项目(WSN-044);江苏省青年医学人才项目(QNRC2016836);镇江市心血管病临床医学研究中心项目(SS2018008)

摘　　要：血管钙化是一个类似于骨、软骨形成且有多因素参与和调控的主动生物学过程。目前临床上对血管钙化的主要治疗策略仍然局限于机械治疗。但随着研究的深入,针对血管钙化的靶向干预已经有越来越多的尝试和探索,包括单纯的化学药物例如磷酸盐结合剂、焦磷酸盐和双膦酸盐、硫代硫酸盐等以及基于OPG/RANK/RANKL信号、破骨细胞等的靶向性干预。但这些干预策略均存在不同程度的缺陷和发展瓶颈,如何能够有效溶解吸收羟基磷灰石结晶、无定形钙沉积,逆转血管壁钙化表型的正常回归,并能充分兼顾骨-血管轴的双向平衡,仍前途漫漫、任重道远。Vascular calcification is an active biological process similar to bone and cartilage formation with multiple regulatory factors involved in.At present,the main clinical treatment strategy for vascular calcification is still limited to mechanical therapy.However,with the progress of research,there have been more and more attempts and explorations for targeted interventions for vascular calcification,including chemical drugs such as phosphate binders,pyrophosphates and bisphosphonates,thiosulfates and targeted intervention in OPG/RANK/RANKL signaling,osteoclasts,etc.However, these intervention strategies have different degrees of defects and development bottlenecks.How to effectively dissolve and absorb hydroxyapatite crystals and amorphous calcium deposits,reverse the progression of vascular wall calcification phenotype and return to normal,and fully take into account the bi-directional balance of bone-vessel axis,is still tough work ahead and a long way to go.

关 键 词：血管钙化 靶向干预 骨 血管轴 

分 类 号：R363[医药卫生—病理学]