枯草杆菌二联活菌肠溶胶囊对乙肝肝硬化患者血清中Th9、IL-9表达影响及与肠道屏障功能的相关性研究  

Correlation between Th9,IL-9 and intestinal barrier function in patients with hepatitis B cirrhosis

作　　者：赵彩红[1] 田志颖[1] 张丽贤[1] 何显[1] 苏新爱[1] ZHAO Cai-hong;TIAN Zhi-ying;ZHANG Li-xian;HE Xian;SU Xin-ai(Digestive System Department,Hengshui Harrison International Peace Hospital,Hengshui 053000,Hebei,China)

机构地区：[1]哈励逊国际和平医院消化内科,河北衡水053000

出　　处：《广东医学》2018年第23期3538-3542,共5页Guangdong Medical Journal

基　　金：河北省科技计划项目(编号:172777109D)

摘　　要：目的探讨枯草杆菌二联活菌肠溶胶囊对乙肝肝硬化患者血清中Th9、IL-9表达影响及与肠道屏障功能的相关性。方法将乙肝肝硬化患者共124例按照入院顺序,根据随机抽签原则分为观察组与对照组各62例。对照组给予常规对症治疗,观察组在对照组治疗的基础上加用枯草杆菌二联活菌肠溶胶囊进行治疗,各治疗14 d,记录与检测治疗前后患者肠道屏障功能、Th9、IL-9、肝脏储备功能的变化。结果两组在治疗期间都无不良反应发生。观察组与对照组的治疗总有效率分别为98. 4%和88. 7%,观察组优于对照组(P <0. 05)。观察组与对照组治疗后的Child-Pugh分级评分与尿液乳果糖/甘露醇排除比明显低于治疗前,观察组治疗后的上述值也较对照组低(P <0. 05)。两组患者治疗后Th9、IL-9都呈现明显下降的趋势,治疗后观察组的Th9、IL-9明显低于对照组(P <0. 05)。Pearson相关分析显示治疗前后患者的尿液乳果糖/甘露醇排除比变化与Th9含量变化呈明显正相关性(r=0. 443,P=0. 003)。结论应用枯草杆菌二联活菌肠溶胶囊能有效改善乙肝肝硬化患者的肠道屏障功能,改善肝脏储备功能并提高治疗效果,有利于调节Th9、IL-9表达水平,且Th9、IL-9与肠道屏障功能存在明显的相关性。Objective To investigate the correlation between Th9,IL-9 and intestinal barrier function in patients with hepatitis B cirrhosis. Methods From January 2016 to May 2017,124 cases with hepatitis B cirrhosis were selected in Hengshui Harrison International Peace Hospital. They were randomly divided into experimental group and control group( n = 62) at admission. The control group was given with routine symptomatic treatment,and the experimental group was treated with live combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules on the basis of the control group. The treatment lasted for 14 d. The intestinal barrier function,Th9,IL-9,hepatic function were recorded. Results There was no adverse reaction in either groups during the treatment period. The total effective rates in the experimental group and the control group were 98. 4% and 88. 7%,respectively; and efficacy in the experimental group was significantly better than that of the control group( P < 0. 05). The scores of Child-Pugh grading and urine lactulose/mannitol removal rate in the experimental group and the control group after treatment were significantly lower than those before treatment; which were significantly more prominent in the experimental group than that in the control group( P <0. 05). After treatment,the Th9,IL-9 was significantly declined in both groups,which was significantly more prominent in the experimental group than the control group( P < 0. 05). Pearson correlation analysis showed that there was significantly positive correlation between urine lactulose/mannitol removal rate and the content of Th9 in patients before and after treatment( r = 0. 443,P = 0. 003). Conclusion The application of live combined Bacillus Subtilis and Enterococcus Faecium enteric-coated capsules in the treatment of patients with hepatitis B cirrhosis can improve the intestinal barrier function in these patients,improve the liver function and treatment efficacy. It regulates the expression of Th9,IL-9,which is significantly correlated with the

关 键 词：枯草杆菌二联活菌肠溶胶囊 TH9 IL-9 乙肝肝硬化 肠道屏障功能 肝脏储备功能 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]