Toll样受体4在急性胰腺炎中的作用  

The role of Toll-like receptor 4 in acute pancreatitis

作　　者：何倩颖 王卫星[1] He Qianying;Wang Weixing(Department of General Surgery,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Digestive System Disease, Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院普通外科,消化系统疾病湖北省重点实验室,湖北武汉430060

出　　处：《中华危重病急救医学》2018年第12期1206-1208,共3页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81370562、81500488).

摘　　要：Toll样受体(TLRs)是一类广泛存在于细胞膜的模式识别受体,属于天然免疫系统成分,可调节机体的炎症反应,参与细胞的信号转导,是特异性免疫和非特异性免疫之间的"桥梁",可以在内源性免疫反应中发挥重要的作用。但由TLRs介导的过度炎症反应可使机体免疫功能失衡,导致多器官功能损害。最早发现的TLR4属于跨膜蛋白,在几乎所有的细胞表面都有表达,大量研究表明其与急性胰腺炎(AP)的发生发展密切相关。本文就TLR4在AP中发挥的作用及机制进行综述,以阐明TLR4与AP病情进展之间的内在联系。Toll-like receptors(TLRs)is a kind of pattern recognition receptor which widely exists on the cell membrane.It is a natural immune system component which can regulate the inflammatory response of the body participating in the signal transduction of cells and play an important role in the endogenous immune response.But the excessive inflammatory reaction initiated by TLRs can make the immune function of the body unbalanced and damage the function of many organs.The earliest discovered TLR4 is a transmembrane protein,almost express in all kinds of cell.Lots of study show it is closely related to the occurrence and development of acute pancreatitis(AP).The role and mechanism of TLR4 in AP will be reviewed in this article.

关 键 词：TOLL样受体4 急性胰腺炎 非特异性免疫 机体免疫功能 过度炎症反应 多器官功能损害 模式识别受体 天然免疫系统 

分 类 号：R576[医药卫生—消化系统]