TRIM29在非小细胞肺癌中表达的Meta分析  

Correlation of TRIM29 expression in non-small cell lung cancer: a meta-analysis

作　　者：赵阳 刘杨 马磊[1,3] 寿涛 相艳[1] 邵党国[1] 熊馨[1] 刘锐[2] Zhao Yang;Liu Yang;Ma Lei;Shou Tao;Xiang Yan;Shao Dangguo;Xiong Xin;Liu Rui(School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650500, China;Department of Medical Oncology, The First People's Hospital of Yunnan Province, Kunming 650032, China;Kunming University of Science and Technology Industry Management Co., Ltd., Kunming 650051, China)

机构地区：[1]昆明理工大学信息工程与自动化学院,650500 [2]云南省第一人民医院肿瘤内科,昆明650032 [3]昆明理工大学科技产业经营管理有限公司,650051

出　　处：《国际生物医学工程杂志》2018年第5期395-400,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金(81760022);国家博士后科学基金(2016M592894XB).

摘　　要：目的 探究TRIM29表达情况与非小细胞肺癌(NSCLC)及其不同组织分型和临床病理特征的相关性。 方法 计算机检索PubMed、EMbase、中国知网和万方数据等数据资料库,收集国内外相关的病例-对照研究,检索文献的时间截至于2018年8月1日。使用Review Manager 5.3软件进行TRIM29阳性表达与其NSCLC的临床病理学特征和组织分型之间关系的Meta分析。 结果 纳入5项研究,其中NSCLC组1 061例,对照组918例。Meta分析结果显示,TRIM29在NSCLC组与对照组[OR=18.32,95%CI(4.62,72.67),P<0.00 01]、鳞癌组与腺癌组[OR=37.05,95%CI(2.45,559.73),P=0.009]、有淋巴结转移组与无淋巴结转移组[OR=5.62,95%CI(2.83,11.17),P<0.000 01]、 (Ⅰ+Ⅱ)期与(Ⅲ+Ⅳ)期[OR=0.18,95%CI(0.10,0.32),P<0.000 01]和高分化组与中低分化组[OR=0.12,95%CI(0.07,0.21),P<0.000 01]中的表达差异均具有统计学意义。 结论 TRIM29的表达与NSCLC及其组织学分类、淋巴结转移、临床分期和组织学分级显著相关,对于NSCLC患者的组织分型和临床病理学特征具有一定帮助和参考价值。Objective To investigate the correlation between TRIM29 expression and non-small cell lung cancer (NSCLC) and its different histological types and clinicopathological features. Methods Using computer retrieves data databases such as PubMed, EMbase, China Knowledge Network and Wanfang Data, and collects relevant case-control studies at home and abroad. The time for searching the literature is as of August 1, 2018. Meta-analysis of the relationship between TRIM29 positive expression and clinicopathological features and tissue typing of non-small cell lung cancer was conducted by Review Manager 5.3 software. Results Five studies were included, including 1 061 in the NSCLC group and 918 in the control group. Meta-analysis showed statistically significant differences between the expression of TRIM29 between NSCLC group and the control group [OR=18.32, 95%CI (4.62, 72.67), P<0.000 1], squamous cell carcinoma and adenocarcinoma group [OR=37.05, 95%CI (2.45, 559.73), P=0.009], NSCLC lymph node metastasis group and NSCLC lymph node without metastasis group [OR=5.62, 95%CI (2.83, 11.17), P<0.000 01], NSCLC (Ⅰ+Ⅱ) and (Ⅲ+Ⅳ) [OR=0.18, 95%CI (0.10, 0.32), P<0.000 01] and NSCLC well differentiated group and the NSCLC middle and low differentiated group [OR=0.12, 95%CI (0.07, 0.21), P<0.000 01], respectively. Conclusions The expression of TRIM29 is significantly correlated with NSCLC and its histological classification, lymph node metastasis, clinical stage and histological grade. This paper has certain help and reference value for the histological and clinical pathological features of NSCLC patients.

关 键 词：TRIM29 非小细胞肺癌 META分析 病例-对照研究 

分 类 号：R734.2[医药卫生—肿瘤]