绝经后女性雌激素水平与急性脑梗死发病的相关性研究  

Relationship between estrogen level and incidence of acute cerebral infarction in postmenopausal women

作　　者：徐艳丽[1] Xu Yanli(Department of Neurology,the Third People's Hospital of Anyang,Anyang 455000,China)

机构地区：[1]河南省安阳市第三人民医院神经内科,455000

出　　处：《中国实用医刊》2018年第22期41-43,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨绝经后女性急性脑梗死患者血浆雌二醇(E2)水平和急性脑梗死发病的关系。方法选取2016年1月至2016年12月安阳市第三人民医院收治的绝经后急性脑梗死女性患者85例,将其作为观察组,并取同时期在医院进行健康体检的健康绝经后女性60例,将其作为对照组,比较两组临床资料。结果观察组血浆雌二醇水平明显低于对照组,差异有统计学意义(P<0.05);雌激素水平的降低并非脑梗死发病的相关危险因素,观察组雌激素水平与胰岛素敏感指数(ISI)、高密度脂蛋白胆固醇(HDL-C)呈现正相关,与高敏C反应蛋白(hs-CRP)、低密度脂蛋白胆固醇(LDL-C)和血浆胰岛素(FINS)水平呈现负相关。结论激素不是绝经后女性发生脑梗死的独立危险因素,雌激素可能通过对绝经后女性机体的炎性指标和代谢产生影响,从而在脑梗死过程中发挥作用。ObjectiveTo investigate the relationship between plasma estradiol (E2) levels and the incidence of acute cerebral infarction in postmenopausal women with acute cerebral infarction.MethodsEighty-five female patients with post-menopausal acute cerebral infarction treated in the Third People's Hospital of Anyang from January 2016 to December 2016 were selected as the observation group and 60 healthy post-menopausal women undergoing physical examination in hospital were selected as the control group. The clinical data of the two groups were compared.ResultsThe plasma estradiol level in the observation group was significantly lower than that in the control group (P<0.05). The decrease of estrogen level was not related to the risk factors of cerebral infarction; estrogen levels in the observation group were positively correlated with insulin sensitivity index (ISI), high density lipoprotein cholesterol (HDL-C), and negatively correlated with high sensitivity C-reactive protein (hs-CRP), low density lipoprotein cholesterol (LDL-C) and plasma insulin (FINS).ConclusionsHormone is not an independent risk factor for cerebral infarction in postmenopausal women. Estrogen may play a role in cerebral infarction by affecting the inflammatory index and metabolism of postmenopausal women.

关 键 词：雌二醇 绝经女性 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]