雷替曲塞联合奥沙利铂治疗中晚期食管癌的疗效  

Effect of raltitrexed combined with oxaliplatin on advanced esophageal cancer

作　　者：杨帆[1] 李德凡[1] 蒋淑年[1] 徐秀娟[1] 赵长新[1] Yang Fan;Li Defan;Jiang Shunian;Xu Xiujuan;Zhao Changxin(The Second People's Hospital of Lianyungang,Lianyungang 222000,China)

机构地区：[1]江苏省连云港市第二人民医院,222000

出　　处：《中国实用医刊》2018年第22期92-93,97,共3页Chinese Journal of Practical Medicine

基　　金：连云港市科技局医学重点学科建设项目(SH1526).

摘　　要：目的探讨雷替曲塞联合奥沙利铂治疗中晚期食管癌的临床效果。方法选择连云港市第二人民医院治疗经病理组织学或细胞学检查确诊为食管癌患者58例,随机分为两组,观察组29例,治疗方案为雷替曲塞联合奥沙利铂;对照组29例,治疗方案为氟尿嘧啶/亚叶酸钙联合奥沙利铂方案。观察比较两组治疗有效率、不良反应及中位生存时间。结果两组患者有效率、中位生存时间比较差异未见统计学意义(P>0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论雷替曲塞联合奥沙利铂方案治疗中晚期食管癌的有效率、中位生存时间和氟尿嘧啶/亚叶酸钙联合奥沙利铂治疗方案相当,但其不良反应发生率较低,值得临床推广应用。Objective To investigate the clinical effect of raltitrexed combined with oxaliplatin on advanced esophageal cancer.Methods Fifty-eight patients with esophageal cancer diagnosed in the Second People's Hospital of Lianyungang by pathological or cytological examination were randomly divided into two groups.The observation group consisted of 29 patients,the regimen was raltitrexed combined with oxaliplatin;and the control group consisted of 29 patients,the regimen was fluorouracil/calcium folate combined with oxaliplatin.The effective rates,adverse reactions and median survival time of the two groups were observed and compared.Results There was no significant difference in the effective rate or median survival time between the two groups (P >0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference between the two groups was significant (P <0.05).Conclusions The effective rate,median survival time of raltitrexed combined with oxaliplatin were similar as fluorouracil/calcium folinate plus oxaliplatin regimen for advanced esophageal cancer,but the incidence of adverse reactions is low,which is worthy of clinical application.

关 键 词：中晚期食管癌 雷替曲塞 奥沙利铂 

分 类 号：R735.1[医药卫生—肿瘤]