蒲参胶囊联合依折麦布治疗高脂血症的临床研究  

Clinical study on Pushen Capsules combined with ezetimibe in treatment of hyperlipidemia

作　　者：刘成功 李万森 杨小东 田艳娟 高大红 LIU Cheng-gong;LI Wan-sen;YANG Xiao-dong;TIAN Yan-juan;GAO Da-hong(Department of General Internal Medicine,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院综合内科,河南驻马店463000

出　　处：《现代药物与临床》2018年第12期3171-3174,共4页Drugs & Clinic

摘　　要：目的探讨蒲参胶囊联合依折麦布片治疗高脂血症的临床疗效。方法选取2017年3月—2018年3月在驻马店市中心医院治疗的高脂血症患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服依折麦布片,10 mg/次,1次/d;治疗组在对照组基础上口服蒲参胶囊,4粒/次,3次/d。两组患者均经过8周治疗。观察两组患者临床疗效,同时比较治疗前后两组患者血脂水平、血管内皮功能和血小板活化功能。结果治疗后,对照组和治疗组临床有效率分别为81.40%和97.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白–胆固醇(LDL-C)水平均显著降低(P<0.05),高密度脂蛋白–胆固醇(HDL-C)水平显著升高(P<0.05),且治疗组血脂水平明显优于对照组(P<0.05)。治疗后,两组内皮素(ET)、CD62P和CD63水平均显著降低(P<0.05),一氧化氮(NO)水平显著升高(P<0.05),且治疗组患者血管内皮功能和血小板活化功能明显优于对照组(P<0.05)。结论蒲参胶囊联合依折麦布片治疗高脂血症可有效改善患者血脂水平、血管内皮功能和血小板活化功能。Objective To investigate the clinical efficacy of Pushen Capsules combined with ezetimibe in treatment of hyperlipidemia. Methods Patients(86 cases) with hyperlipidemia in Zhumadian Central Hospital from March 2017 to March 2018 were divided into control(43 cases) and treatment(43 cases) groups according to different treatments. Patients in the control group were po administered with Ezetimibe Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Pushen Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood lipid levels, the vascular endothelial function and platelet activation function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.40% and 97.67% respectively, and there were differences between two groups(P < 0.05). After treatment, the TC, TG and LDL-C levels in two groups were significantly decreased(P < 0.05), but HDL-C levels were significantly increased(P < 0.05), and the blood lipid levels in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the ET, CD62 P and CD63 levels in two groups were significantly decreased(P < 0.05), but NO levels were significantly increased(P < 0.05), and the vascular endothelial and platelet activation function in the treatment group was significantly better than those in the control group(P < 0.05). Conclusion Pushen Capsules combined with ezetimibe in treatment of hyperlipidemia can effectively improve the blood lipid levels, the vascular endothelial and platelet activation function.

关 键 词：蒲参胶囊 依折麦布片 高脂血症 血脂水平 血管内皮功能 血小板活化功能 高密度脂蛋白-胆固醇 

分 类 号：R914[医药卫生—药物化学]