抑郁障碍躯体症状的生物学机制  

Biological mechanisms of somatic symptoms in depressive disorder

作　　者：耿纪婷 阎锐[1] 姚志剑[1] Geng Jiting;Yan Rui;Yao Zhijian(Department of Psychiarty,Affiliated Nanjing Brain Hospital of Nanjing Medical University,Nanfing 210029, China)

机构地区：[1]南京医科大学附属脑科医院精神科,南京210029

出　　处：《中华行为医学与脑科学杂志》2018年第12期1148-1152,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(81571639,81371522);江苏省科技强卫青年医学人才项目(QNRC2016050);江苏省重点研发计划项目(BE2018609);南京市科技发展计划项目(YKK15110).

摘　　要：抑郁障碍的临床表现可归纳为情感症状、认知症状和躯体症状三个维度,多数抑郁障碍患者存在各种躯体症状,躯体症状的存在常与病情较重、疗效不佳、病程迁延等有关。伴躯体症状的抑郁障碍可能是抑郁障碍的特殊亚型,对此类患者的生物学机制的探索具有重要意义。本文从抑郁障碍躯体症状的临床特征、定义及生物学机制进行系统综述,以期为抑郁障碍病理机制的研究提供借鉴。The symptoms of depressive disorder can be summarized into three dimensions: emotional symptoms,cognitive symptoms and somatic symptoms.Most patients with depressive disorders have various somatic symptoms.The existence of somatic symptoms is often related to the severity of the disease,poor efficacy,and prolonged disease duration.Depressive disorder with somatic symptoms may be a special subtype of depressive disorder.Therefore exploration for its biological mechanisms has an important significance in such patients.This article reviews the clinical characteristics,definitions,and biological mechanisms of somatic symptoms in depressive disorder,and hopes to contribute to an improved understanding of the pathology of depressive disorders.

关 键 词：抑郁障碍 躯体症状 生物学机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]