酒精性脂肪性肝病的严重程度和腹腔内脂肪面积以及血清炎症因子相关性分析  

Correlation analysis of the severity of alcoholic fatty liver disease,fat area in the abdominal cavity and serum inflammatory factors

作　　者：王海舫[1] 黄静[1] 张岁[1] 贾蓓[1] 杨大伟[1] 柳立平[1] 马文波[1] 解从君[1] 刘明书[1] Wang Haifang;Huang Jing;Zhang Sui;Jia Bei;Yang Dawei;Liu Liping;Ma Wenbo;Xie Congjun;Liu Mingshu(Liver Disease Center,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]河北医科大学第一医院肝病中心,石家庄050031

出　　处：《中国综合临床》2019年第1期36-40,共5页Clinical Medicine of China

基　　金：河北省卫生厅科研基金项目(20180217).

摘　　要：目的探讨酒精性脂肪性肝病(alcoholic fatty liver disease,AFLD)严重程度和腹腔内脂肪面积以及血清炎症因子白细胞介素18(interleukin-18,IL-18)和白细胞介素8(interleukin-8,IL-8)的相关性。方法选取2016年10月至2017年10月就诊于河北医科大学第一医院的120例AFLD患者,根据彩超脂肪病变程度分为轻、中、重3组,其中轻度患者40例,中度患者50例,重度患者30例,选择同期体检健康者40名作为对照,所有参与者行CT扫描,检测腹腔内脂肪面积(intra-abdominal fat area,VAT)、腹壁皮下脂肪面积(abdominalsubcutaneous adipose area,SAT)以及腹部脂肪总面积(total area of the abdominal fat,TA),采用生化分析仪检测肝功能,采用酶联免疫法(enzyme-linked immunoassay,ELSIA)检测IL-18的浓度,采用放射免疫法检测IL-8的浓度,然后进行对比分析。结果健康对照组与轻、中、重度AFLD组VAT分别为(70.28±10.19)、(114.38±9.97)、(146.73±10.19)、(163.38±12.69) cm2;健康对照组与轻、中、重度AFLD组TA分别为(256.72±34.56)、(332.19±33.28)、(387.49±32.28)、(478.19±31.02) cm^2;健康对照组与轻、中、重度AFLD组SAT分别为(156.23±28.19)、(203.43±27.12)、(246.19±26.89)、(271.19±27.94) cm^2;健康对照组与轻、中、重度AFLD组天冬氨酸氨基转移酶(aspartate aminotransferase,AST)的浓度分别为(18.50±1.12)、(23.50±1.21)、(25.50±1.24)、(29.50±1.43) U/L;健康对照组与轻、中、重度AFLD组丙胺酸胺基转移酶(alanine aminotransferase,ALT)的浓度分别为(18.50±2.14)、(26.50±2.22)、(35.50±2.34)、(38.50±2.11) U/L;健康对照组与轻、中、重度AFLD组γ谷氨酰转移酶(γ-glutamyltransferase,γ-GT)的浓度分别为(16.50±2.11)、(32.50±2.23)、(47.50±2.31)、(48.00±2.43) U/L。与健康对照组比较,轻、中、重度AFLD组VAT、TA、SAT、AST、ALT、γ-GT差异均有统计学意义(P均<0.05),与轻度AFLD组比较,中、重度AFLD组VAT、TA、SAT、AST、ALT、γ-GT均有统计学意义(P均<0.05)Objective To investigate the correlation between the severity of alcoholic fatty liver disease and the amount of fat in the abdominal cavity and the serum inflammatory factor IL-18 and IL-8.Methods From October 2016 to October 2017, one hundred and twenty patients with AFLD in the First Hospital of Hebei Medical University were divided into light, medium, heavy groups according to the severity of fatty lesions by color Doppler Ultrasound.There were 40 mild patients, 50 moderate patients and 30 severe patients.Forty healthy subjects were selected as controls.All the participants underwent CT scanning.The intra-abdominal fat area (VAT), abdominal subcutaneous fat area (SAT) and total abdominal fat area (TA) were measured.The liver function was measured by biochemical analyzer and enzyme-linked immunoassay (ELISA). (ELSIA) IL-18 was detected and IL-8 was detected by radioimmunoassay.Results The VAT of the healthy control group and the mild, medium and severe AFLD group were (70.28±10.19), (114.38 ± 9.97), (146.73±10.19), (163.38±12.69) cm^2.The TA of the healthy control group and the mild, medium and severe AFLD group were (256.72±34.56), (332.19 ±33.28), (387.49±32.28), (478.19 ±31.02) cm^2.The SAT of the healthy control group and the light, medium and severe AFLD group were (156.23±28.19), (203.43±27.12), (246.19±26.89), (271.19 ±27.94) cm^2, respectively.Aspartate aminotransferase (AST) of the healthy control group and the mild, medium and severe AFLD group were (18.50±1.12), (23.50±1.21), (25.50±1.24), (29.50± 1.43) U/L.Alanine aminotransferase (ALT) of the healthy control group and the light, medium and severe AFLD group were (18.50±2.14), (26.50±2.22), (35.50±2.34), (38.50±2.11) U/L.γ-glutamyltransferaseof the healthy control group and the light, medium and severe AFLD group were (16.50±2.11), (32.50±2.23), (47.50±2.31), (48.00±2.43) U/L, respectively.Compared with the healthy control group, VAT, TA, SAT, AST, ALT andγ-GT in the light, medium and heavy AFLD group showed statistically

关 键 词：酒精性脂肪性肝病 腹腔内脂肪面积 白细胞介素18 白细胞介素8 

分 类 号：R575.5[医药卫生—消化系统]