生物标志物用于肺癌早期诊断的研究进展  

Advance in application of biomarkers in early diagnosis of lung cancer

作　　者：马小 刘宝刚[1] Ma Xiao;Liu Baogang(Respiratory Depatment ,Harbin Medical University Cancer Hospital ,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院呼吸内科,150086

出　　处：《中国综合临床》2019年第1期92-96,共5页Clinical Medicine of China

摘　　要：肺癌是最常见的恶性肿瘤类型之一,并且发病率和病死率居癌症之首,提高早期肺癌的诊断率对改善患者的预后非常重要。肺癌的发生、发展是多基因、多个信号通路介导的复杂过程。生物标志物的检测在肺癌早期诊断中受到极大的关注。随着研究的深入和检测技术的进步,肺癌自身抗体、外泌体、循环肿瘤细胞(circulating tumor cell,CTC)、循环肿瘤DNA(circulating tumor DNA,ctDNA)、DNA甲基化等生物标志物不断被发现,精准医疗深入人心。现就生物标志物在肺癌早期诊断领域的研究进展作一概要介绍。Objective Lung cancer is one of the most common types of malignancy, and the incidence and mortality are the highest among cancers.Increasing the diagnostic rate of early-stage lung cancer is very important to improve the prognosis of patients.The occurrence and development of lung cancer is a complex process mediated by multiple genes and multiple signaling pathways.The detection of biomarkers has received great attention in the early diagnosis of lung cancer.With the deepening of research and advances in detection technology, biomarkers such as autoantibodies, exosomes, circulating tumor cells, circulating tumor DNA, and DNA methylation of lung cancer have been continuously discovered, and precision medicine has been deeply rooted in the hearts of people.This article gives an overview of the research progress of biomarkers in the early diagnosis of lung cancer.

关 键 词：肺癌 早期诊断 生物标志物 

分 类 号：R734.2[医药卫生—肿瘤]