中药血清药物化学的方法学概述及应用领域研究进展  

An Overview of Methodology and Research Progress on Application of Serum Pharmacochemistry of Traditional Chinese Medicine

作　　者：武晓伟 郝艳艳 聂春霞 倪艳[1] 郝旭亮[1] 刘聪[1] WU Xiao-wei;HAO Yan-yan;NIE Chun-xia;NI Yan;HAO Xu-liang;LIU Cong(Shanxi Provincial Academy of Traditional Chinese Medicirie ,Taiyuan 030012,China;Shanxi University of Chinese Medicine,Taiyuan 030619,China)

机构地区：[1]山西省中医药研究院,太原030012 [2]山西中医药大学,太原030619

出　　处：《中国实验方剂学杂志》2019年第3期173-179,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山西省中药现代化关键技术研究振东专项(2016ZD0402)

摘　　要：中药血清药物化学是以鉴别口服中药后血清中移行成分为基础的一种新兴研究方法,经过20多年的发展,中药血清药物化学得到了广泛的认可与应用。该文通过查阅近年来国内外相关文献,围绕实验动物的选择、灌胃液的制备、给药方案的设计、采血方式及采血时间的确定、含药血清的前处理、血清样品的分析等关键步骤对中药血清药物化学的方法学进行了归纳,并着重综述了中药血清药物化学在阐明中药药效物质基础、建立中药质量标准、阐明复方配伍机制三方面的应用。在此基础上,分析其可能存在的一些问题,展望其发展与应用前景,旨在使人们对中药血清药物化学有一个全方位的认知,为其在中医药研究中更好的应用提供参考。Serum pharmacochemistry of traditional Chinese medicine( TCM) is a new subject based on the identification of migrating components in serum after oral administration of TCM. After more than 20 years of development,serum pharmacochemistry of TCM has been widely recognized and applied by researchers. Based on the references related with the serum pharmacochemistry from these years,the research summarized the methods of serum pharmacochemistry of TCM, for example, selection of experimental animals, preparation of gastric irrigation,design of drug administration scheme, method and time of adoption blood, pretreatment of serum containing drug,as well as analysis of serum sample. In addition,the paper will emphatically introduce the application of serum pharmacochemistryof TCM, which includes clarifying the substance basis of Chinese medicine,establishing the quality standard of TCM, and clarifying the compatibility of compound Chinese medicine. At the same time, we will through some existing problems to look forward to the future of serum pharmacochemistryof TCM,so that people can have a comprehensive understanding of serum pharmacochemistryof TCM,hoping to lay a foundation for the further application of this method in TCM research.

关 键 词：中药血清药物化学 方法学 应用 给药方案 质量标准 配伍机制 物质基础 

分 类 号：R22[医药卫生—中医基础理论] R285[医药卫生—中医学]