少腹逐瘀胶囊联合内美通治疗子宫肌瘤伴痛经的疗效及可能机制研究  

Curative effect and possible mechanism of Shaofuzhuyu capsule combined with gestrinone capsule in treatment of uterine fibroids complicated with dysmenorrhea

作　　者：房玥 徐铁锋[2] 李蕊[3] 孙丹华[1] FANG Yue;XU Tie-Feng;LI Rui(Department of Obstetrics and Gynecology,Harbor Hospital of Hebei Port Group Company Limited,Qinhuangdao,Hebei 055002,China)

机构地区：[1]河北港口集团有限公司港口医院妇产科,河北秦皇岛066002 [2]河北港口集团有限公司港口医院中医科,河北秦皇岛066002 [3]河北港口集团有限公司港口医院手术室,河北秦皇岛066002

出　　处：《中国妇幼保健》2019年第1期25-28,共4页Maternal and Child Health Care of China

基　　金：河北省2013年医学科学研究重点课题(20130051)

摘　　要：目的探析少腹逐瘀胶囊联合内美通治疗子宫肌瘤伴痛经的疗效及可能机制。方法选择本院妇科2014年3月-2017年3月收治的100例子宫肌瘤伴痛经患者,按照随机数表法分为对照组和治疗组,各50例。对照组口服内美通6个月,治疗组在对照组基础上加用少腹逐瘀胶囊。比较两组治疗6个月的子宫肌瘤总有效率,治疗前与治疗6个月的痛经程度,治疗前、治疗3个月及治疗6个月的血清黄体生成激素(LH)、雌二醇(E2)、白介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)水平,并记录两组治疗期间的不良反应总发生率。结果治疗组与对照组的肌瘤体积缩小比分别为(53. 35±10. 42)%和(50. 04±10. 01)%,治疗总有效率分别为96%和88%,差异均无统计学意义(均P>0. 05)。两组治疗前的痛经程度分级比较,差异无统计学意义(P>0. 05)。治疗后两组痛经程度均减轻,治疗组整体痛经程度显著轻于对照组,差异有统计学意义(P<0. 05)。两组治疗前的血清E2、LH、IL-6及TNF-α水平比较,差异均无统计学意义(均P>0. 05)。治疗后3个月与6个月,两组血清E2、LH、IL-6及TNF-α水平均较治疗前显著降低,差异均有统计学意义(均P<0. 05)。治疗组治疗后3个月与6个月的血清E2、LH、IL-6及TNF-α水平均显著低于对照组(均P<0. 05)。治疗组与对照组治疗期间不良反应总发生率分别为12%与8%,差异无统计学意义(P>0. 05)。结论内美通联合少腹逐瘀胶囊治疗子宫肌瘤可有效缩小肌瘤体积,并促进血清性激素与炎性因子的进一步消退,对痛经的缓解效果更佳,值得推广。Objective To explore the curative effect and possible mechanism of Shaofuzhuyu capsule combined with gestrinone capsule in treatment of uterine fibroids complicated with dysmenorrhea.Methods A total of 100 patients with uterine fibroids and dysmenorrhea treated in Harbor Hospital of Hebei Port Group Company Limited from March 2014 to March 2017 were selected and divided into control group and treatment group according to random number table,50 patients in each group.The patients in control group were treated by oral administration of gestrinone capsule for 6 months,the patients in treatment group were treated by oral administration of gestrinone capsule combined with Shaofuzhuyu capsule.The total effective rates at 6 months after treatment,dysmenorrheal degrees before treatment and at 6 months after treatment,the levels of serum luteinizing hormone(LH),estradiol(E2),interleukin 6(IL-6),and tumor necrosis factor-α(TNF-α) before treatment,at 3 and 6 months after treatment were compared between the two groups.The total incidence rates of adverse reactions in the two groups were recorded.Results The reduction ratio of fibroids size in treatment group and control group were(53.35±10.42) % and(50.04±10.01) %,respectively,and the total effective rates were 96% and 88%,respectively,the differences were not statistically significant(P >0.05).There was no statistically significant difference in dysmenorrheal degree between the two groups before treatment(P >0.05).The degree of dysmenorrhea after treatment reduced in the two groups,and the overall dysmenorrheal degree in treatment group was statistically significantly lighter than that in control group(P<0.05).There was no statistically significant difference in serum levels of E2,LH,IL-6,and TNF-α between the two groups before treatment(P >0.05).The levels of serum E2,LH,IL-6,and TNF-α at 3 and 6 months after treatment in the two groups were statistically significantly lower than those before treatment(P<0.05).The levels of serum E2,LH,IL-6,and TNF-α at 3 and 6 mont

关 键 词：子宫肌瘤 痛经 少腹逐瘀胶囊 内美通 

分 类 号：R737.3[医药卫生—肿瘤]