检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:张勇[1] 杨中振 余昕玲 程旭[1] 李伟剑 郭令妹 海俐[1] 郭丽[1] 吴勇[1] Zhang Yong;Yang Zhongzhen;Yu Xinling;Cheng Xu;Li Weijian;Guo Lingmei;Hai Li;Guo Li;Wu Yong(Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041)
出 处:《有机化学》2018年第12期3211-3218,共8页Chinese Journal of Organic Chemistry
基 金:supported by the National Natural Science Foundation of China(Nos.81373259,81573286,81602954)~~
摘 要:开发了一种通过钌(Ⅲ)催化的N-导向碳氢活化反应来直接合成羟甲基化芳烃衍生物的新方法.该方法的底物适用范围广泛,室温条件下即可以较高收率制得目标产物.为化学结构中含有羟甲基的生物活性化合物的合成提供了新的思路.Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(Ⅲ)-catalyzed nitrogen atom directed C-H activation is described. The reaction proceeds smoothly at room temperature and generates the corresponding products in moderate to excellent yields. Meanwhile, it has a broad substrate scope and opens up an attractive avenue for the application of direct hydroxymethylation in the synthesis of biologically active compounds.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.200