光相干断层扫描血管成像在遗传性视网膜脉络膜变性疾病中的应用研究现状  

Current research status of optical coherence tomography angiography in hereditary retinochoroidal degeneration

作　　者：王霄娜[1,2] 彭晓燕 Wang Xiaona;Peng Xiaoyan(Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China;the Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third Hospital, Beijing 100191, China)

机构地区：[1]北京市眼科研究所、首都医科大学附属北京同仁医院、北京市眼科学与视觉科学重点实验室,100730 [2]北京大学第三医院眼科、眼部神经损伤的重建保护与康复北京市重点实验室,100191

出　　处：《中华眼底病杂志》2019年第1期86-90,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：北京市眼科研究所引领计划 (201503);首都医科大学附属北京同仁医院重点医学专业发展计划 (trzdyxzy201801).

摘　　要：作为一种快速、无创、可量化的血管成像新技术,OCT血管成像(OCTA)尤其适合应用于视网膜色素变性、Best卵黄样黄斑营养不良、成人型卵黄样黄斑营养不良、蜂巢状视网膜营养不良、无脉络膜症及Stargardt病等遗传性视网膜脉络膜变性疾病患者的长期随访。在随访过程中,临床医生可以从血管成像中发现解释疾病发展的细微征象,对血流密度进行定量化描述,及时发现脉络膜新生血管并尽早治疗,对这些疾病的病因探索、病程监控有着重要的临床意义。随着该类疾病更多治疗方式的开展,OCTA相关参数还可以作为评判和比较不同治疗效果的指标。未来更多的OCTA量化指标将应用于评价遗传性视网膜脉络膜变性疾病的病程变化,为临床的早期诊断和治疗提供宝贵依据。OCT angiography (OCTA) is a fast, noninvasive and quantifiable new technique, which is especially suitable for long-term follow-up in patients with hereditary retinochoroidal degeneration, such as retinitis pigmentosa, Best vitelliform macular dystrophy, adult onset foveomacular vitelliform dystrophy, doyne honeycomb retinal dystrophy, choroideremia and Stargardt disease. During the follow-up, clinicians can find the subtle signs that explain disease development from the blood flow imaging, quantitatively describe the vascular density, timely detect and treat choroidal neovascularization. It is significant to explore the etiology and monitor the course of these diseases. With the development of more treatments for these diseases, OCTA parameters can also be used as indicators to evaluate and compare different therapeutic effects. In the future, more quantitative indicators of OCTA will be applied to evaluate the course of hereditary retinochoroidal degeneration, and provide valuable basis for early diagnosis and treatment.

关 键 词：体层摄影术 光学相干 视网膜疾病/诊断 脉络膜疾病/诊断 眼疾病 遗传性 综述 

分 类 号：R774.1[医药卫生—眼科] R773.4[医药卫生—临床医学]