MMP与VEGF在原发肾癌组织中的表达及其与肾癌临床特征和预后的相关性  

Expression of MMP and VEGF in Primary Renal Cell Carcinoma and its Relationship with Clinical Features and Prognosis of Renal Cell Carcinoma

作　　者：代宏亮[1] 杨静哲[1] 陈小均[1] 王成李[1] DAI Hong-liang;YANG Jing-zhe;CHEN Xiao-jun(Dongfang Hospital of Beijing University of Traditional Chinese Medicine,100078,Beijing)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《医学临床研究》2018年第12期2349-2351,共3页Journal of Clinical Research

摘　　要：【目的】探讨基质金属蛋白酶(MMP)、血管内皮生长因子(VEGF)在原发肾细胞癌组织中的表达及与其临床特征和预后的相关性。【方法】选取2009年1月至2014年6月本院收治的72例肾细胞癌患者的临床资料;采用免疫组化染色观察肾癌组织中MMP-2、MMP-9和VEGF的表达情况;并采用非条件Logistic回归分析MMP-2、MMP-9、VEGF表达与肾细胞癌患者临床特征和预后的相关性。【结果】肾细胞癌组织中MMP-2、MMP-9、VEGF表达水平均随着TNM分期升高逐渐升高;各分期之间比较差异均具有统计学意义(P<0.05)。本组3年存活50例(存活组);死亡22例(死亡组);存活组TNM分期Ⅰ+Ⅱ期患者所占比例高于死亡组(P<0.05);死亡组MMP2、MMP-9、VEGF表达水平均高于存活组;差异均具有统计学意义(P<0.05)。 TNM分期、MMP-2、MMP-9、VEGF是影响肾细胞癌患者预后的主要危险因素(OR值分别为1.326、1.559、1.734、1.846;P<0.05)。【结论】肾细胞癌组织中MMP-2、MMP-9、VEGF表达与TNM分期相关;并随着TNM分期升高而升高;MMP-2、MMP-9、VEGF是影响 肾细胞癌患者预后的危险因素。【Objective】 To investigate the expression of MMP and VEGF in primary renal cell carcinoma and its relationship with clinical features and prognosis of renal cell carcinoma. 【Methods】 A total of 72 cases of renal cell carcinoma confirmed by pathology in our hospital from January 2009 to June 2014 were selected, immunohistochemical staining was used to observe the expression of MMP-2, MMP-9 and VEGF in renal cell carcinoma, and the relationship between MMP-2, MMP-9 and VEGF expression and renal cell carcinoma was studied by unconditional Logistic regression. 【Results】 The expression of MMP-2,MMP-9,VEGF in renal cell carcinoma (RCC) increased gradually with the increase of TNM stage, and the difference was statistically significant among the different stages (P<0.05). In this group, 50 cases survived (the survival group), 22 cases died (the death group), the proportion of TNM stage Ⅰ-Ⅱ patients in the survival group was higher than that in death group (P<0.05). The expression of MMP2, MMP-9,VEGF in the dead group was significantly higher than that in the survival group (P<0.05). In TNM stage, MMP-2, MMP-9,VEGF was the main risk factor for the prognosis of renal cell carcinoma (OR=1.326, 1.559, 1.734, 1.846,P<0.05 ).【Conclusion】 The expression of MMP-2, MMP-9, VEGF in renal cell carcinoma is correlated with TNM stage and increases with the increase of TNM stage. MMP-2,MMP-9,VEGF are risk factors for the prognosis of renal cell carcinoma.

关 键 词：肾肿瘤 基质金属蛋白酶类/代谢 血管内皮生长因子类/代谢 

分 类 号：R737.11[医药卫生—肿瘤]